University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY, USA.
Norton Leatherman Spine Center, 210 E Gray Street, Suite 900, Louisville, KY, USA.
J Orthop Surg Res. 2021 Jan 14;16(1):57. doi: 10.1186/s13018-021-02205-y.
Recent work has shed light on the potential benefits of cannabinoids for multimodal pain control following orthopedic procedures. The objective of this review was to summarize the available evidence of analgesic and opioid-sparing effects cannabinoids have in orthopedic surgery and identify adverse events associated with their use.
A systematic review of the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines including PubMed, EMBASE, MEDLINE, PsycINFO, and Google Scholar was performed to include all primary, therapeutic studies published on the use of cannabis, and cannabis-derived products in orthopedic surgery.
The literature review returned 4292 citations. Thirteen publications were found to meet inclusion criteria. Four randomized controlled trials were evaluated while the remaining studies were of quasi-experimental design.
Research on cannabinoids in orthopedic surgery is mostly of a quasi-experimental nature and is mainly derived from studies where orthopedics was not the primary focus. The overall results demonstrate potential usefulness of cannabinoids as adjunctive analgesics and in mitigating opioid use. However, the current evidence is far from convincing. There is a need to produce rigorous evidence with well-designed randomized controlled trials specific to orthopedic surgery to further establish these effects.
最近的研究揭示了大麻素在骨科手术后多模式疼痛控制中的潜在益处。本综述的目的是总结大麻素在骨科手术中具有镇痛和减少阿片类药物作用的现有证据，并确定与使用相关的不良事件。
使用系统评价和荟萃分析的首选报告项目（PRISMA）指南对文献进行系统回顾，包括 PubMed、EMBASE、MEDLINE、PsycINFO 和 Google Scholar，以纳入所有关于大麻和大麻衍生产品在骨科手术中使用的原始治疗研究。
文献综述共返回 4292 条引文。发现有 13 篇出版物符合纳入标准。评估了 4 项随机对照试验，而其余研究为准实验设计。
骨科手术中关于大麻素的研究主要是准实验性质的，主要来源于以骨科为主要重点的研究。总体结果表明大麻素作为辅助镇痛药和减轻阿片类药物使用的潜在有用性。然而，目前的证据远非令人信服。需要制定专门针对骨科手术的严格设计的随机对照试验来进一步确定这些效果。
