室温区域选择性脱苄基环醚化反应
Room Temperature Regioselective Debenzylative Cycloetherification Reaction.
作者信息
Kwain Samuel, McMillen Colin D, Whitehead Daniel C
机构信息
Department of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina 29634, United States.
出版信息
ACS Omega. 2024 Sep 26;9(40):41355-41360. doi: 10.1021/acsomega.4c04016. eCollection 2024 Oct 8.
A regio- and stereoselective debenzylative cycloetherification (DBCE) reaction of protected hexoses to form stereodefined hydroxylated tetrahydrofurans of synthetic utility has been investigated under very mild room temperature reaction conditions. This study revealed the potential application of the DBCE reaction of simple, abundant starting materials to access stereochemically rich tetrahydrofuran compounds under mild reaction conditions.
在非常温和的室温反应条件下，研究了受保护己糖的区域和立体选择性脱苄基环醚化（DBCE）反应，以形成具有合成效用的立体定义的羟基化四氢呋喃。这项研究揭示了简单、丰富的起始原料的DBCE反应在温和反应条件下获得立体化学丰富的四氢呋喃化合物的潜在应用。
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