He Jing, Lin Nan, Jin Ting, Lin Ming, Huang Zuowei, Li Shuxian, Liu Jinling, Su Lin, Ye Xian, Wu Lei, Song Zhenghong, Xu Hongzhen, Chen Zhimin
Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, People's Republic of China.
Nursing Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, People's Republic of China.
J Asthma Allergy. 2024 Oct 7;17:965-975. doi: 10.2147/JAA.S480676. eCollection 2024.
Allergic conditions, identified as a significant global health challenge, are profoundly influenced by indoor allergens, especially house dust mites (HDM). Yet the relationship between mite sensitized components and respiratory allergies and asthma control remains poorly understood.
A cohort of 96 children, either with allergic rhinitis (AR) or rhinitis with asthma syndrome (ARAS), was assessed. Protein microarray technology was deployed to quantify sIgE responses to the allergenic components of Der p and Der f.
The study cohort comprised 18 AR and 78 ARAS patients; with 43 mild and 53 moderate-to-severe AR; with 28 uncontrolled, 21 partially controlled, and 29 well-controlled asthma. Sensitization prevalence for HDM components was highest with Der p (97.9%), Der f 2 (97.9%), Der p 2 (94.8%), Der f 1(94.8%), Der p 1 (93.8%), Der p 23 (57.3%). Notably, sIgE concentrations for Der f and Der f 2 were significantly greater in the ARAS compared to AR (P < 0.05). While sIgE levels varied between mild and moderate-to-severe AR, the differences were not statistically significant (P > 0.05). However, Der p 23 sIgE levels demonstrated a significant fluctuation across the asthma control strata (P < 0.05), with the well-controlled group exhibiting the lowest readings.
The sIgE levels to HDM allergens were higher in ARAS group compared to AR group, especially Der f and Der f 2, indicating an association between sIgE reactivity and the diagnosis of asthma. Reduced Der p 23 sIgE levels were indicative of enhanced asthma control.
过敏疾病被视为一项重大的全球健康挑战，受到室内过敏原的深刻影响，尤其是屋尘螨（HDM）。然而，螨致敏成分与呼吸道过敏及哮喘控制之间的关系仍知之甚少。
对96名患有过敏性鼻炎（AR）或鼻炎伴哮喘综合征（ARAS）的儿童进行了评估。采用蛋白质芯片技术定量检测对Der p和Der f变应原成分的特异性IgE（sIgE）反应。
研究队列包括18名AR患者和78名ARAS患者；其中43名轻度AR患者和53名中重度AR患者；28名哮喘未控制患者、21名部分控制患者和29名控制良好的哮喘患者。屋尘螨成分的致敏率以Der p最高（97.9%），其次是Der f 2（97.9%）、Der p 2（94.8%）、Der f 1（94.8%）、Der p 1（93.8%）、Der p 23（57.3%）。值得注意的是，与AR患者相比，ARAS患者中Der f和Der f 2的sIgE浓度显著更高（P < 0.05）。虽然轻度和中重度AR患者的sIgE水平有所不同，但差异无统计学意义（P > 0.05）。然而，Der p 23的sIgE水平在哮喘控制分层中呈现显著波动（P < 0.05），控制良好组的读数最低。
与AR组相比，ARAS组对屋尘螨变应原的sIgE水平更高，尤其是Der f和Der f 2，表明sIgE反应性与哮喘诊断之间存在关联。Der p 23的sIgE水平降低表明哮喘控制得到改善。
