原发性骨质疏松症中的肠道微生物群：一项系统综述。
Gut Microbiota in Primary Osteoporosis: a Systematic Review.
作者信息
Ji Jiangxun, Cai Feihong, Yuan Chunchun, Huang Chen, Zhang Haitao, Xu Chuanglong, Suo Wendong, Zhu Wenhao, Shi Binhao, Tang Dezhi, Wang Yongjun
机构信息
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032 China.
Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, 200032 China.
出版信息
Phenomics. 2024 Jul 12;4(3):293-297. doi: 10.1007/s43657-024-00164-y. eCollection 2024 Jun.
UNLABELLED
The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review encompassing 10 studies that employed high-throughput sequencing methodologies. Notably, the taxonomic profiles exhibited pronounced heterogeneity across reviewed studies. A combined analysis of mechanistical studies screened out potential targets for osteoporosis prevention and treatment. We appraised the limitations in previous studies, and proposed suggestions for optimizing sequencing techniques and experimental designs. Larger-size longitudinal cohorts based on multi-omics and extended phenotypes are recommended to comprehensively characterize the involvement of GM in the pathogenesis of osteoporosis.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s43657-024-00164-y.
未标注
肠道微生物群（GM）与原发性骨质疏松症之间的联系已引起广泛关注。在本研究中，我们进行了一项系统综述，涵盖了10项采用高通量测序方法的研究。值得注意的是，在纳入综述的研究中，分类学特征表现出明显的异质性。对机制研究的综合分析筛选出了骨质疏松症预防和治疗的潜在靶点。我们评估了先前研究中的局限性，并提出了优化测序技术和实验设计的建议。建议开展基于多组学和扩展表型的更大规模纵向队列研究，以全面表征肠道微生物群在骨质疏松症发病机制中的作用。
补充信息
在线版本包含可在10.1007/s43657-024-00164-y获取的补充材料。
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