de Oliveira S L, Ibanez O M, Mouton D, Sant'Anna O A, Siqueira M, Biozzi G
Seçao d'Immunologia, Instituto Biologico, Sao Paulo, Brazil.
Exp Clin Immunogenet. 1985;2(4):223-33.
The intensity of delayed-type hypersensitivity (DTH) expression measured by footpad swelling was established in high and low antibody responder lines of mice produced by bidirectional selective breeding for antibody responsiveness to different antigens. These lines of mice presented a very large difference in antibody response to the antigens used in each selective breeding (selection Ags) and to several other unrelated Ags (nonspecific effect). The intensity of DTH reactivity to selection Ags and to unrelated Ags differed in the various lines investigated, but the intensity of DTH reactions was not correlated with antibody responsiveness. The results of the present article demonstrated that the expression of DTH reactivity and antibody responsiveness to the same antigens are polygenic characters subject to independent quantitative regulation.
通过足垫肿胀测量的迟发型超敏反应（DTH）表达强度，在双向选择性培育产生的高抗体应答和低抗体应答小鼠品系中得以确立，这些小鼠品系针对不同抗原的抗体应答能力经过了双向选择性培育。这些小鼠品系对每次选择性培育中使用的抗原（选择抗原）以及其他几种不相关抗原（非特异性效应）的抗体反应存在很大差异。在所研究的各个品系中，对选择抗原和不相关抗原的DTH反应强度有所不同，但DTH反应强度与抗体应答能力并无关联。本文结果表明，对相同抗原的DTH反应性和抗体应答能力的表达是受独立定量调控的多基因性状。
