Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, Mexico.
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México City, Mexico.
Curr Opin Microbiol. 2023 Dec;76:102399. doi: 10.1016/j.mib.2023.102399. Epub 2023 Oct 29.
Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern cellular responses to diverse environmental cues. These systems rely on phosphoryl-group transfers between histidine- and aspartate-containing modules of sensor histidine kinase and response regulator proteins. TCS diversity is shaped by the ecological niche of the bacterium, resulting in significant population-level variations. Consequently, orthologous TCSs can display considerable divergence throughout the signaling process. Here, we venture into the mechanisms governing the emergence of TCS variation, and explore the adaptation of orthologous TCS in bacteria with dissimilar lifestyles. The peculiar features of the bacterial adaptive response A/ultraviolet light repair Y (BarA/UvrY) and anoxic redox control B/anoxic redox control A (ArcB/ArcA) and their ortholog TCSs illustrate the remarkable capacity of TCSs to evolve and finely tune their signaling mechanisms, effectively addressing specific environmental challenges.
细菌双组分系统 (TCS) 是一种多功能的信号转导机制，可调控细胞对各种环境信号的响应。这些系统依赖于传感器组氨酸激酶和反应调节蛋白中含有组氨酸和天冬氨酸的模块之间的磷酸基团转移。TCS 的多样性由细菌的生态位塑造，导致在种群水平上存在显著的差异。因此，在整个信号转导过程中，直系同源的 TCS 可能会表现出相当大的差异。在这里，我们探讨了调控 TCS 变异出现的机制，并研究了具有不同生活方式的细菌中直系同源 TCS 的适应。细菌适应性反应 A/紫外线修复 Y (BarA/UvrY) 和缺氧氧化还原控制 B/缺氧氧化还原控制 A (ArcB/ArcA) 及其直系同源 TCS 的特殊特征说明了 TCS 进化和精细调节其信号转导机制的惊人能力，有效地应对了特定的环境挑战。
