Yang Jiarong, Zheng Jianhua
NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102629, China.
Curr Med Chem. 2024 Oct 11. doi: 10.2174/0109298673346264241008110105.
Tuberculosis (TB) is a leading cause of death from a single infectious disease worldwide. Early and accurate diagnosis is advantageous for timely detection and prompt treatment, thereby reducing the risk of disease transmission, which is essential for effective TB control. Biomarkers provide a valuable resource for TB diagnosis. Proteomic technologies have emerged as a powerful tool in biomarker discovery. In this perspective, we explore how proteomic technologies contribute to the discovery of TB diagnostic biomarkers. We also address the challenges and discuss prospective methods to augment the performance of biomarkers in diagnosing TB.
结核病（TB）是全球单一传染病致死的主要原因。早期准确诊断有利于及时发现并迅速治疗，从而降低疾病传播风险，这对于有效控制结核病至关重要。生物标志物为结核病诊断提供了宝贵资源。蛋白质组学技术已成为发现生物标志物的有力工具。从这个角度出发，我们探讨蛋白质组学技术如何助力结核病诊断生物标志物的发现。我们还阐述了面临的挑战，并讨论提高生物标志物诊断结核病性能的前瞻性方法。
