Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, P.R. China.
Gynecol Endocrinol. 2023 Dec;39(1):2254844. doi: 10.1080/09513590.2023.2254844.
Endometriosis has been reported to be associated with metabolism-related diseases, such as hypercholesterolemia and diabetes, while no studies have reported the association between endometriosis and metabolic syndrome.
This study aims to explore the association between endometriosis and metabolic syndrome. Also, the association between endometriosis and single metabolic syndrome indicator was explored.
This was a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES). A total of 2389 participants were finally included for analysis, with 2212 in the non-endometriosis group and 177 in the endometriosis group. Association between endometriosis and metabolic syndrome was explored using multivariate logistic regression analysis, with results shown as odds ratio (OR) with 95% confidence intervals (95%CI). Association between endometriosis and single metabolic syndrome indicator was explored using multivariate liner regression analysis.
After adjusting age, race, education level, family poverty to income ratio (PIR), smoking, age at menarche, gravidity, menopause, female hormones use, and dyslipidemia drug use, endometriosis was associated with the higher odds of metabolic syndrome (OR = 1.55, 95%CI: 1.01-2.35). Further adjusting hysterectomy or oophorectomy, we found the similar association despite no statistical significance (OR = 1.47, 95%CI: 0.96-2.25). Moreover, we found endometriosis was associated with the high level of triglyceride (TG) ( = 0.38, 95%CI: 0.06-0.70).
Our study found the association between endometriosis and metabolic conditions, indicating that metabolic conditions of endometriosis women should be focused, and monitoring the blood lipid levels may be significant in decreasing the risk of metabolic syndrome.
子宫内膜异位症与血脂异常和糖尿病等代谢相关疾病有关，而目前尚无研究报道子宫内膜异位症与代谢综合征之间的关系。
本研究旨在探讨子宫内膜异位症与代谢综合征之间的关系。此外，还探讨了子宫内膜异位症与单个代谢综合征指标之间的关系。
这是一项基于全国健康和营养检查调查（NHANES）的横断面研究。最终共纳入 2389 名参与者进行分析，其中非子宫内膜异位症组 2212 人，子宫内膜异位症组 177 人。采用多变量逻辑回归分析探讨子宫内膜异位症与代谢综合征之间的关系，结果以比值比（OR）和 95%置信区间（95%CI）表示。采用多元线性回归分析探讨子宫内膜异位症与单个代谢综合征指标之间的关系。
在校正年龄、种族、教育程度、家庭贫困与收入比（PIR）、吸烟、初潮年龄、孕次、绝经、激素使用和血脂异常药物使用后，子宫内膜异位症与代谢综合征的发生风险较高相关（OR=1.55，95%CI：1.01-2.35）。进一步调整子宫切除术或卵巢切除术，尽管无统计学意义，但我们发现仍存在相似的关联（OR=1.47，95%CI：0.96-2.25）。此外，我们发现子宫内膜异位症与甘油三酯（TG）水平升高有关（β=0.38，95%CI：0.06-0.70）。
本研究发现子宫内膜异位症与代谢状况之间存在关联，表明应关注子宫内膜异位症女性的代谢状况，监测血脂水平可能对降低代谢综合征的风险具有重要意义。
