Yu Chao, Zhou Wei, Zhou Xinlei, Zhu Lingjuan, Wang Tao, Bao Huihui, Cheng Xiaoshu
Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China.
Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang of Jiangxi, China.
J Clin Hypertens (Greenwich). 2024 Dec;26(12):1433-1440. doi: 10.1111/jch.14913. Epub 2024 Oct 13.
This study aimed to examine the association between the triglyceride-glucose (TyG) index and chronic kidney disease (CKD) in normotensive adults with hypertension and further investigate potential effect modifiers of this association. A total of 7975 normoweight hypertensive participants were enrolled from the Chinese H-type hypertension registry (CHHRS) cohort. The TyG index was calculated using the formula: ln (fasting triglyceride [mg/dL] × fasting plasma glucose [mg/dL])/2. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m of body surface area. Multivariate logistic regression analysis revealed a 50% increased risk of CKD (OR: 1.50, 95% CI: 1.26-1.79) for each unit increase in the TyG index. A linear dose-response relationship between the TyG index and CKD risk was observed using restricted cubic spline analysis. Compared to the first quartile of the TyG index, the fourth quartile showed a significantly higher risk of CKD (OR: 1.88; 95% CI: 1.41-2.50). Subgroup analysis identified a stronger association between the TyG index and CKD risk in males and individuals with a history of alcohol consumption (all p values for interaction < 0.05). In conclusions, the TyG index was significantly associated with an increased risk of CKD in normoweight adults with hypertension, particularly in males and those with a history of alcohol consumption.
本研究旨在探讨甘油三酯-葡萄糖（TyG）指数与血压正常的高血压成年患者慢性肾脏病（CKD）之间的关联，并进一步研究该关联的潜在效应修饰因素。从中国H型高血压注册研究（CHHRS）队列中纳入了7975名体重正常的高血压参与者。TyG指数采用公式计算：ln（空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]）/2。CKD定义为估计肾小球滤过率（eGFR）<60 mL/min/1.73 m²体表面积。多因素逻辑回归分析显示，TyG指数每增加一个单位，CKD风险增加50%（比值比：1.50，95%置信区间：1.26-1.79）。采用限制性立方样条分析观察到TyG指数与CKD风险之间存在线性剂量反应关系。与TyG指数的第一个四分位数相比，第四个四分位数的CKD风险显著更高（比值比：1.88；95%置信区间：1.41-2.50）。亚组分析发现，TyG指数与男性以及有饮酒史个体的CKD风险之间的关联更强（所有交互作用的p值<0.05）。总之，TyG指数与体重正常的高血压成年患者CKD风险增加显著相关，尤其是男性和有饮酒史的患者。
