Skogastierna Carin, Kalay Nazli, Swolin-Eide Diana, Holmgren Anton
Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Pediatrics, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
Acta Paediatr. 2025 Mar;114(3):526-535. doi: 10.1111/apa.17460. Epub 2024 Oct 14.
This study investigated the association between gestational age and birth size with pubertal timing, measured as peak height velocity, and adult height.
This retrospective, population-based study was conducted in Sweden in 2023. A sub-group of the 1974 and 1990 GrowUp Gothenburg cohorts was used (n = 4700, 50% males). The subgroup consisted of healthy individuals with Nordic ethnicity, known parental heights and measured adult heights. Data on birth characteristics (gestational age, birth length, birth weight) were collected. Pubertal timing was assessed as age at peak height velocity. Univariable linear regression analysis and bivariate correlations were conducted to answer the research questions.
Gestational age was not associated with age at peak height velocity or adult height. Birth length and weight could explain 12% and 8% (p ≤ 0.001) respectively of attained adult height. However, birth length and birth weight could only explain the variation in age at peak height velocity to a small degree.
This study showed that gestational age is not associated with age at peak height velocity or adult height. A positive relationship was found between birth size, particularly birth length, and adult height. No strong associations were found between birth size and age at peak height velocity.
本研究调查了以身高增长峰值速度衡量的青春期发育时间以及成人身高与胎龄和出生体重之间的关联。
这项基于人群的回顾性研究于2023年在瑞典开展。使用了1974年和1990年哥德堡成长队列的一个亚组（n = 4700，50%为男性）。该亚组由具有北欧血统、已知父母身高且测量了成人身高的健康个体组成。收集了出生特征（胎龄、出生身长、出生体重）的数据。青春期发育时间评估为身高增长峰值速度时的年龄。进行单变量线性回归分析和双变量相关性分析以回答研究问题。
胎龄与身高增长峰值速度时的年龄或成人身高无关。出生身长和出生体重分别能解释成人身高的12%和8%（p≤0.001）。然而，出生身长和出生体重只能在很小程度上解释身高增长峰值速度时年龄的变化。
本研究表明，胎龄与身高增长峰值速度时的年龄或成人身高无关。发现出生体重，尤其是出生身长，与成人身高呈正相关。未发现出生体重与身高增长峰值速度时的年龄之间有强烈关联。
