Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Longhu Waihuan East Road, Zhengdong New District, Zhengzhou, 450018, Henan, China.
Sci Rep. 2024 Oct 14;14(1):24043. doi: 10.1038/s41598-024-74302-x.
Pulmonary embolism is a rare but serious complication in Mycoplasma pneumoniae pneumonia patients, leading to serious sequelae and even death. We aim to retrospectively analyze the clinical features of Mycoplasma pneumoniae pneumonia with pulmonary consolidation in children and to explore the independent risk factors for progression to pulmonary embolism. Clinical data of 207 children with Mycoplasma pneumoniae pneumonia complicated with pulmonary consolidation were collected, and the patients were divided into the pulmonary embolism group (69 patients) and the control group (138 patients). Multivariate logistic regression was used to analyze the risk factors and the predictive efficacy was evaluated by receiver operating characteristic curve. Multivariate logistic regression analysis showed that fever days, D-dimer, immunoglobulin A, chest pain, extra-respiratory symptoms, plastic bronchitis and cutaneous mucosal system complications were the independent risk factors. Fever days ≥ 7.5, D-dimer ≥ 0.895 mg/L, immunoglobulin A ≥ 1.015 g/L, chest pain, extra-respiratory symptoms, plastic bronchitis and cutaneous mucous system complications significantly increased the risk of pulmonary embolism in children with Mycoplasma pneumoniae pneumonia complicated with pulmonary consolidation.
肺栓塞是肺炎支原体肺炎患者罕见但严重的并发症，可导致严重的后遗症，甚至死亡。我们旨在回顾性分析儿童肺部实变型肺炎支原体肺炎的临床特征，并探讨进展为肺栓塞的独立危险因素。收集了 207 例合并肺部实变的肺炎支原体肺炎患儿的临床资料，将患儿分为肺栓塞组（69 例）和对照组（138 例）。采用多因素逻辑回归分析危险因素，并通过受试者工作特征曲线评估预测效能。多因素逻辑回归分析显示，发热天数、D-二聚体、免疫球蛋白 A、胸痛、呼吸系统外症状、塑型性支气管炎和皮肤黏膜系统并发症是独立危险因素。发热天数≥7.5d、D-二聚体≥0.895mg/L、免疫球蛋白 A≥1.015g/L、胸痛、呼吸系统外症状、塑型性支气管炎和皮肤黏膜系统并发症显著增加儿童肺部实变型肺炎支原体肺炎并发肺栓塞的风险。
