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动物在生物医学研究中持续具有的重要性。

The continued importance of animals in biomedical research.

作者信息

Chang Michael C J, Grieder Franziska B

机构信息

Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Lab Anim (NY). 2024 Nov;53(11):295-297. doi: 10.1038/s41684-024-01458-4.

DOI:10.1038/s41684-024-01458-4
PMID:39402213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11518981/
Abstract

In the rapidly evolving field of biomedical research, the role of animal models has long been a topic of scientific and ethical debate. However, despite advancements in alternative modeling approaches, animal models remain an essential component of scientific discovery and medical advancement.

摘要

在快速发展的生物医学研究领域，动物模型的作用长期以来一直是科学和伦理辩论的主题。然而，尽管替代建模方法取得了进展，但动物模型仍然是科学发现和医学进步的重要组成部分。

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Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research.人源化小鼠作为癌症免疫治疗研究的重要临床前模型。
Front Oncol. 2021 Nov 18;11:784947. doi: 10.3389/fonc.2021.784947. eCollection 2021.
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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.用于快速鉴定候选抗病毒治疗药物和预防药物的人呼吸道芯片。
Nat Biomed Eng. 2021 Aug;5(8):815-829. doi: 10.1038/s41551-021-00718-9. Epub 2021 May 3.
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J Transl Autoimmun. 2019 Nov 11;2:100021. doi: 10.1016/j.jtauto.2019.100021. eCollection 2019 Dec.
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Are in vitro and in silico approaches used appropriately for animal-based major depressive disorder research?是否在基于动物的重度抑郁症研究中恰当地使用了体外和计算机模拟方法？
PLoS One. 2020 Jun 24;15(6):e0233954. doi: 10.1371/journal.pone.0233954. eCollection 2020.
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.叙利亚仓鼠作为 SARS-CoV-2 感染及对策研发的小动物模型。
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