昼夜节律对登革病毒传播和复制的调节：对媒介活动和病毒动力学的深入了解。
Circadian regulation of dengue virus transmission and replication: insights into vector activity and viral dynamics.
机构信息
Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
出版信息
Front Cell Infect Microbiol. 2024 Sep 30;14:1482042. doi: 10.3389/fcimb.2024.1482042. eCollection 2024.
Abstract
Dengue fever, caused by dengue virus, poses a significant global health challenge, particularly in tropical regions where serves as the primary vector. The circadian clock governs key behavioral and physiological processes, including activity patterns, feeding behaviors, and susceptibility to dengue virus infection. This article explores the influence of circadian rhythms on the mosquito's ability to transmit dengue virus, emphasizing how the circadian regulation of gene expression, immune responses, and lipid metabolism in the mosquito vector creates temporal windows that affect viral replication efficiency.
摘要
登革热是由登革病毒引起的，是一项重大的全球健康挑战，特别是在热带地区，埃及伊蚊是主要的传播媒介。生物钟调节着关键的行为和生理过程，包括活动模式、摄食行为以及对登革病毒感染的易感性。本文探讨了生物钟对蚊子传播登革病毒能力的影响，强调了蚊子媒介中基因表达、免疫反应和脂质代谢的生物钟调节如何创造影响病毒复制效率的时间窗口。
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本文引用的文献
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Effects of circadian clock disruption on gene expression and biological processes in Aedes aegypti.生物钟紊乱对埃及伊蚊基因表达和生物过程的影响。
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Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.睡眠：吸血节肢动物生物学中一个重要但研究不足的过程。
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Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease.天然产物作为登革热病毒抑制剂的最新进展，特别关注 NS2b/NS3 蛋白酶。
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