多囊卵巢综合征少女的抑郁、焦虑和自尊：系统评价和荟萃分析。
Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis.
机构信息
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Department of Nursing, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
出版信息
Front Endocrinol (Lausanne). 2024 Sep 30;15:1399580. doi: 10.3389/fendo.2024.1399580. eCollection 2024.
OBJECTIVE
Studies have shown the adverse psychological impact of polycystic ovary syndrome (PCOS), but the state of mental health in adolescents with PCOS remains unclear. Thus, we performed a systematic review and meta-analysis to investigate the prevalence and severity of depression and anxiety, as well as potential effects on self-esteem and quality of life (QoL) in this specific population.
METHODS
We systematically searched four electronic databases: PubMed, Embase, Web of Science, and the Cochrane Reviews database for articles published until 25/8/2024. We considered observational studies in which the subjects were adolescent girls with PCOS who had reported symptoms including anxiety, depression, self-esteem, and QoL. The Review Manager version 5.4 was used to analyze the available data extracted. We used the Newcastle-Ottawa Quality Assessment Scale (NOS) to evaluate the quality of selected studies. A funnel plot was utilized to assess the risk of literature bias, and a forest plot was used to represent the combined outcomes. This systematic review was previously registered in PROSPERO with the registration number CRD42022382036.
RESULTS
We included 11 studies in the systematic review and conducted meta-analyses on 10 of them. Adolescents with PCOS reported a higher risk of depression (OR = 2.21, 95% CI: 1.23 to 4.00, p = 0.008) and a higher level of depression scores (SMD = 0.43, 95% CI: 0.16 to 0.71, p = 0.002) than controls. There were no significant differences in anxiety (OR = 1.90, 95% CI: 0.52 to 6.96, p = 0.33; SMD = 0.19, 95% CI: -0.21 to 0.59, p = 0.36), self-esteem (SMD = -0.17, 95% CI: -0.85 to 0.52, p = 0.64), and QoL (SMD = -0.15, 95% CI: -0.42 to 0.11, p = 0.26) between the two groups.
CONCLUSIONS
Our research indicated that adolescents with PCOS experienced more severe depressive symptoms than those without PCOS. This highlights the importance of evaluation and early treatment of mental health in PCOS. More clinicians should pay attention to the mental health of adolescent girls with PCOS through this study.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022382036.
目的
研究表明多囊卵巢综合征（PCOS）会对患者造成不良心理影响，但 PCOS 青少年的心理健康状况仍不清楚。因此，我们进行了系统评价和荟萃分析，以调查该特定人群中抑郁和焦虑的患病率和严重程度，以及对自尊和生活质量（QoL）的潜在影响。
方法
我们系统地检索了四个电子数据库：PubMed、Embase、Web of Science 和 Cochrane Reviews 数据库，以获取截至 2024 年 8 月 25 日发表的文章。我们考虑了观察性研究，其中受试者为患有 PCOS 的青春期女孩，她们报告了包括焦虑、抑郁、自尊和 QoL 在内的症状。使用 Review Manager 版本 5.4 分析提取的可用数据。我们使用纽卡斯尔-渥太华质量评估量表（NOS）来评估所选研究的质量。使用漏斗图评估文献偏倚的风险，使用森林图表示合并结果。本系统评价已在 PROSPERO 中预先注册，注册号为 CRD42022382036。
结果
我们纳入了 11 项系统评价研究，并对其中 10 项进行了荟萃分析。与对照组相比，患有 PCOS 的青少年报告抑郁风险更高（OR = 2.21，95%CI：1.23-4.00，p = 0.008）和抑郁评分更高（SMD = 0.43，95%CI：0.16-0.71，p = 0.002）。两组之间焦虑（OR = 1.90，95%CI：0.52-6.96，p = 0.33；SMD = 0.19，95%CI：-0.21-0.59，p = 0.36）、自尊（SMD = -0.17，95%CI：-0.85-0.52，p = 0.64）和 QoL（SMD = -0.15，95%CI：-0.42-0.11，p = 0.26）差异无统计学意义。
结论
我们的研究表明，患有 PCOS 的青少年比没有 PCOS 的青少年经历更严重的抑郁症状。这凸显了评估和早期治疗 PCOS 患者心理健康的重要性。更多的临床医生应该通过这项研究关注患有 PCOS 的青春期女孩的心理健康。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO/，标识符 CRD42022382036。
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