Sherwood J B, Goldwasser E, Chilcote R, Carmichael L D, Nagel R L
Blood. 1986 Jan;67(1):46-9.
We have studied serum immunoreactive erythropoietin (SIE) levels in 28 patients with sickle cell anemia (SCA) without renal insufficiency and in 17 patients with nonhemoglobinopathy anemias of comparable severity using a sensitive radioimmunoassay procedure. An exponential relationship between SIE level and degree of anemia was noted in all patients. However, in nonhemoglobinopathy anemia, a sharp rise in the SIE level occurred as hemoglobin (Hb) levels fell below about 12 g/dL, whereas in sickle cell patients the increase was not marked until hemoglobin fell to about 9 g/dL. The response was more blunted in older SCA patients than in younger ones. A linear regression model relating SIE level to Hb level, presence/absence of SCA, and age explained 63% of the variation in SIE. We conclude that the serum erythropoietin levels in SCA increased at a lower hemoglobin concentration and are of a lower magnitude than that of the other anemias.
我们使用灵敏的放射免疫分析方法，研究了28例无肾功能不全的镰状细胞贫血（SCA）患者以及17例病情严重程度相当的非血红蛋白病性贫血患者的血清免疫反应性促红细胞生成素（SIE）水平。在所有患者中均发现SIE水平与贫血程度呈指数关系。然而，在非血红蛋白病性贫血中，当血红蛋白（Hb）水平降至约12 g/dL以下时，SIE水平急剧上升，而在镰状细胞贫血患者中，直到血红蛋白降至约9 g/dL时，这种升高才较为明显。年龄较大的SCA患者的反应比年轻患者更为迟钝。一个将SIE水平与Hb水平、是否患有SCA以及年龄相关联的线性回归模型解释了SIE变异的63%。我们得出结论，SCA患者的血清促红细胞生成素水平在较低的血红蛋白浓度时升高，且升高幅度低于其他贫血患者。
