Chen Junzhi, Zhou Wenjing, Huang Yan
Division of Nephrology, South China Hospital of Shenzhen University, Shenzhen, China.
Division of Nephrology, South China Hospital of Shenzhen University, Shenzhen, China.
J Affect Disord. 2024 Apr 1;350:240-246. doi: 10.1016/j.jad.2024.01.108. Epub 2024 Jan 12.
The menopause-specific relationship between serum uric acid (SUA) and depressive symptoms were not known. We aimed to explore the association between SUA and depressive symptoms stratified by menopausal status.
This is a cross-sectional study, a total of 4845 females were enrolled from China health and retirement longitudinal study (CHARLS) in China. The Center for Epidemiologic Studies Depression Scale (CESD) were used to measure depressive symptoms. A cut-off score of CES-D ≥ 10 was defined as depression. Multiple regression models were used to assess the relationship between SUA and depression stratified by menopausal status.
Overall, SUA was significantly associated with depressive symptoms/depression in post-menopause women (β = -0.39, 95 % CI: -0.60, -0.17) after adjusted potential confounders. Compared with those whose SUA levels were in the first tertile, participants with their SUA in the second (β = -0.76, 95 % CI: -1.30, -0.22) and third tertile (β = -1.24, 95 % CI: -1.80, -0.68) had milder depressive symptoms. However, SUA was not associated with depressive symptoms in pre-menopause women (β = 0.1, 95 % CI: -0.25, 0.46). An interaction between menopausal status and SUA on depressive symptoms were found in this study (P = 0.02). Similar results were found for depression.
Some potential covariates like diet that could affect SUA levels were not considered in this study.
Higher SUA was associated with depressive symptoms/depression in post-menopause women. An interaction between menopausal status and SUA on depressive symptoms were found. SUA was not associated with depressive symptoms/depression in pre-menopause women.
血清尿酸（SUA）与抑郁症状之间特定于更年期的关系尚不清楚。我们旨在探讨按绝经状态分层的SUA与抑郁症状之间的关联。
这是一项横断面研究，共纳入了来自中国健康与养老追踪调查（CHARLS）的4845名女性。采用流行病学研究中心抑郁量表（CESD）来测量抑郁症状。CES-D得分≥10被定义为抑郁。使用多元回归模型评估按绝经状态分层的SUA与抑郁之间的关系。
总体而言，在调整潜在混杂因素后，绝经后女性的SUA与抑郁症状/抑郁显著相关（β = -0.39，95%置信区间：-0.60，-0.17）。与SUA水平处于第一三分位数的参与者相比，SUA处于第二（β = -0.76，95%置信区间：-1.30，-0.22）和第三三分位数（β = -1.24，95%置信区间：-1.80，-0.68）的参与者抑郁症状较轻。然而，绝经前女性的SUA与抑郁症状无关（β = 0.1，95%置信区间：-0.25，0.46）。本研究发现绝经状态和SUA对抑郁症状存在交互作用（P = 0.02）。抑郁方面也发现了类似结果。
本研究未考虑一些可能影响SUA水平的潜在协变量，如饮食。
较高的SUA与绝经后女性的抑郁症状/抑郁相关。发现绝经状态和SUA对抑郁症状存在交互作用。绝经前女性的SUA与抑郁症状/抑郁无关。
