Lightman A, Brandes J M, Binur N, Drugan A, Zinder O
Clin Chem. 1986 Jan;32(1 Pt 1):101-3.
We measured copper and zinc in serum (n = 82) and tumor tissue (n = 41) from women with a palpable pelvic mass, admitted for suspected ovarian tumor. In serum, copper was increased and zinc decreased in the group (n = 40) subsequently proven to have a malignant ovarian tumor. The mean copper/zinc ratio in this group was 2.30 (SD 0.41), significantly (p less than 0.001) higher than for the benign group (n = 42), 1.43 (SD 0.22). In tumor tissue the concentrations of copper and zinc followed the same pattern, the copper/zinc ratio being significantly (p less than 0.001) higher in the malignant (0.158, SD 0.065) tumors than in the benign tissue (0.093, SD 0.04). We conclude that the Cu/Zn ratio in serum reliably (specifically) indicates the presence of advanced ovarian malignant tumor. The decreased concentrations of zinc and the increased concentrations of copper in serum do not seem to result from a shift of zinc into or release of copper out of the malignant tumor tissue.
我们对因疑似卵巢肿瘤而入院的、可触及盆腔肿块的女性患者的血清（n = 82）和肿瘤组织（n = 41）进行了铜和锌含量的测定。在血清中，随后被证实患有恶性卵巢肿瘤的组（n = 40）中铜含量升高而锌含量降低。该组的平均铜/锌比值为2.30（标准差0.41），显著高于良性组（n = 42）的1.43（标准差0.22）（p < 0.001）。在肿瘤组织中，铜和锌的浓度呈现相同模式，恶性肿瘤（0.158，标准差0.065）中的铜/锌比值显著高于良性组织（0.093，标准差0.04）（p < 0.001）。我们得出结论，血清中的铜/锌比值能够可靠地（尤其是）指示晚期卵巢恶性肿瘤的存在。血清中锌浓度降低和铜浓度升高似乎并非源于锌向恶性肿瘤组织内的转移或铜从恶性肿瘤组织中的释放。
