Fabris C, Farini R, Del Favero G, Gurrieri G, Piccoli A, Sturniolo G C, Panucci A, Naccarato R
Clin Biochem. 1985 Dec;18(6):373-5. doi: 10.1016/s0009-9120(85)80078-3.
Serum copper and zinc levels and their ratio were evaluated in 48 control subjects, 29 patients with pancreatic cancer, 46 with chronic pancreatitis and 32 with extra-pancreatic diseases, with the purpose of ascertaining modifications in chronic pancreatic disease. Hepatic involvement and age were also investigated as possible factors influencing results. Cu/Zn ratio was found to be significantly increased in pancreatic cancer (2.66 +/- 0.16, mean +/- SE) as compared to controls (1.39 +/- 0.06, p less than 0.001), chronic pancreatitis (1.82 +/- 0.09. p less than 0.001) and extra-pancreatic diseases (1.81 +/- 0.18, p less than 0.001), but without practical clinical value. Serum zinc levels appear to decrease with age, while copper and Cu/Zn ratio increase. However, covariance analysis demonstrated that age does not play an important role in influencing copper and Cu/Zn ratio. A decreased liver synthetic function, at least in part age-related, seems to be an additional factor in decreasing serum zinc values.
对48名对照者、29名胰腺癌患者、46名慢性胰腺炎患者和32名胰腺外疾病患者的血清铜、锌水平及其比值进行了评估，目的是确定慢性胰腺疾病中的变化情况。还研究了肝脏受累情况和年龄作为可能影响结果的因素。结果发现，与对照者（1.39±0.06，p<0.001）、慢性胰腺炎患者（1.82±0.09，p<0.001）和胰腺外疾病患者（1.81±0.18，p<0.001）相比，胰腺癌患者的铜/锌比值显著升高（2.66±0.16，均值±标准误），但无实际临床价值。血清锌水平似乎随年龄增长而降低，而铜和铜/锌比值则升高。然而，协方差分析表明年龄在影响铜和铜/锌比值方面并不起重要作用。肝脏合成功能下降，至少部分与年龄相关，似乎是血清锌值降低的另一个因素。
