基因表达的表观遗传调控与生物控制和癌症：细胞周期调控机制的保真度。
Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle.
机构信息
Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, USA.
出版信息
Results Probl Cell Differ. 2022;70:375-396. doi: 10.1007/978-3-031-06573-6_13.
The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.
细胞周期受到严格的表观遗传机制的调控，这些机制响应内在和外在的调节信号，支持 DNA 复制和细胞分裂的保真度。我们将重点关注：（1）对控制增殖至关重要且在癌症中受损的复杂且相互依存的过程；（2）与细胞周期不同阶段相关的表观遗传和拓扑结构域，这些结构域可能在癌症的发生和发展中发生改变；（3）有丝分裂书签的需求，以维持转录调控机制在核内的定位，从而在整个细胞周期中增强细胞身份，防止恶性转化。
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