Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Results Probl Cell Differ. 2024;74:291-296. doi: 10.1007/978-3-031-65944-7_11.
Owing to its reduced bone density and higher risk for fractures, osteoporosis remains an international public health crisis. Research highlights the essential role played by macrophage polarization in osteoporosis and indicates that the balance between pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages influences bone metabolism. This review examines how M1 and M2 macrophages contribute to the development of osteoporosis and evaluates existing therapeutic approaches aimed at controlling macrophage polarization. It also describes future study areas that will allow improved management and treatment of osteoporosis.
由于其骨密度降低和骨折风险增加，骨质疏松症仍然是一个国际公共健康危机。研究强调了巨噬细胞极化在骨质疏松症中的重要作用，并表明促炎 M1 巨噬细胞和抗炎 M2 巨噬细胞之间的平衡影响着骨代谢。本综述探讨了 M1 和 M2 巨噬细胞如何促进骨质疏松症的发展，并评估了现有的控制巨噬细胞极化的治疗方法。它还描述了未来的研究领域，这将有助于改善骨质疏松症的管理和治疗。
