• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

儿童及青年皮质纤维性骨缺损与非骨化性纤维瘤:28例放射学特征分析及文献复习

Cortical fibrous defects and non-ossifying fibromas in children and young adults: The analysis of radiological features in 28 cases and a review of literature.

作者信息

Błaż Marcin, Palczewski Piotr, Swiątkowski Jan, Gołębiowski Marek

机构信息

1 Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.

出版信息

Pol J Radiol. 2011 Oct;76(4):32-9.

PMID:22802852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3389949/
Abstract

BACKGROUND

To assess and describe the variability of radiological presentations of fibrous cortical defects and non-ossifying fibromas in children and young adults.

MATERIAL/METHODS: Medical records of 28 patients (15 males, 13 females, mean age of 17 years) with a radiological diagnosis of cortical fibrous defect or non-ossifying fibroma were reviewed retrospectively. The presentation of the lesion, its location and morphology according to Ritschl's classification, as well as the number and types of imaging studies performed in the study group were assessed.

RESULTS

Almost all lesions constituted an incidental finding discovered on plain films performed due to trauma. One lesion presented with a pathological fracture. There were 4 patients (mean age of 11 years) with stage A lesion, 9 patients (mean age of 16 years) with stage B lesion, 10 patients (mean age of 18 years) with stage C lesion, and 5 patients (mean age of 23 years) with stage D lesion. The lesions were located mostly in bones around the knee joint. In more than a half of the patients, further imaging was performed apart from plain films. Four lesions were biopsied (1 of stage B and 3 of stage C).

CONCLUSIONS

A considerable morphological variability of cortical fibrous defects and non-ossifying fibromas, especially of stage C, seems to be the main cause of unnecessary additional imaging and invasive diagnostic procedures in patients with this benign pathology. The knowledge of their age-related evolution and typical skeletal distribution should help in making a correct diagnosis.

摘要

背景

评估并描述儿童及青年纤维性皮质缺损和非骨化性纤维瘤的放射学表现的变异性。

材料/方法:回顾性分析28例经放射学诊断为皮质纤维性缺损或非骨化性纤维瘤患者(15例男性,13例女性,平均年龄17岁)的病历。评估病变的表现、根据里施尔分类法的病变位置和形态,以及研究组中进行的影像学检查的数量和类型。

结果

几乎所有病变都是因外伤进行X线平片检查时偶然发现的。1例病变出现病理性骨折。有4例(平均年龄11岁)为A期病变患者,9例(平均年龄16岁)为B期病变患者,10例(平均年龄18岁)为C期病变患者,5例(平均年龄23岁)为D期病变患者。病变大多位于膝关节周围的骨骼。超过一半的患者除X线平片外还进行了其他影像学检查。4例病变进行了活检(1例B期和3例C期)。

结论

皮质纤维性缺损和非骨化性纤维瘤,尤其是C期,存在相当大的形态变异性,这似乎是导致患有这种良性病变的患者进行不必要的额外影像学检查和侵入性诊断程序的主要原因。了解其与年龄相关的演变及典型的骨骼分布情况应有助于做出正确诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/cee1373de6b1/poljradiol-76-4-32-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/bad2a7283eb4/poljradiol-76-4-32-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/ef8152f4e2ab/poljradiol-76-4-32-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/78c38f0d7cd8/poljradiol-76-4-32-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/c2bdd220ca42/poljradiol-76-4-32-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/4106ab0b7d7e/poljradiol-76-4-32-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/bde693fd24e0/poljradiol-76-4-32-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/cee1373de6b1/poljradiol-76-4-32-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/bad2a7283eb4/poljradiol-76-4-32-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/ef8152f4e2ab/poljradiol-76-4-32-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/78c38f0d7cd8/poljradiol-76-4-32-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/c2bdd220ca42/poljradiol-76-4-32-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/4106ab0b7d7e/poljradiol-76-4-32-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/bde693fd24e0/poljradiol-76-4-32-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c95/3389949/cee1373de6b1/poljradiol-76-4-32-g007.jpg

相似文献

1
Cortical fibrous defects and non-ossifying fibromas in children and young adults: The analysis of radiological features in 28 cases and a review of literature.儿童及青年皮质纤维性骨缺损与非骨化性纤维瘤:28例放射学特征分析及文献复习
Pol J Radiol. 2011 Oct;76(4):32-9.
2
Are Fibrous Cortical Defects (FCDs) and Non-Ossifying Fibromas (NOFs) Only Radiological Findings? The Relationship between Radiological/Clinical Findings and Physical Activity in Children and Adolescents: A Cross-Sectional Study.纤维性骨皮质缺损(FCDs)和非骨化性纤维瘤(NOFs)仅是影像学表现吗?儿童和青少年影像学/临床发现与身体活动之间的关系:一项横断面研究。
J Clin Med. 2024 Sep 27;13(19):5751. doi: 10.3390/jcm13195751.
3
Fatigue-type stress fractures of the lower limb associated with fibrous cortical defects/non-ossifying fibromas in the skeletally immature.下肢疲劳型应力性骨折与未成熟骨骼中的纤维皮质缺损/非骨化性纤维瘤相关。
Clin Radiol. 2010 May;65(5):382-6. doi: 10.1016/j.crad.2010.01.014. Epub 2010 Mar 23.
4
Scintigraphic characteristics of non-ossifying fibroma in military recruits undergoing bone scintigraphy for suspected stress fractures and lower limb pains.在因疑似应力性骨折和下肢疼痛接受骨闪烁扫描的新兵中,非骨化性纤维瘤的闪烁扫描特征。
Nucl Med Commun. 2007 Jan;28(1):25-33. doi: 10.1097/MNM.0b013e328012e3de.
5
Non-ossifying fibromas and fibrous cortical defects around the knee - an epidemiologic survey in a Japanese pediatric population.膝关节周围非骨化性纤维瘤和纤维性皮质缺损:日本儿科人群的一项流行病学调查。
BMC Musculoskelet Disord. 2022 Apr 22;23(1):378. doi: 10.1186/s12891-022-05330-9.
6
[Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma) (author's transl)].
Rofo. 1981 Feb;134(2):169-77. doi: 10.1055/s-2008-1056330.
7
Surgical treatment for symptomatic non-ossifying fibromas of the lower extremity with calcium sulfate grafts in skeletally immature patients.在骨骼未成熟患者中,使用硫酸钙移植物对下肢有症状的非骨化性纤维瘤进行手术治疗。
Eur J Orthop Surg Traumatol. 2018 Feb;28(2):291-297. doi: 10.1007/s00590-017-2028-3. Epub 2017 Aug 17.
8
Retrospective Analysis of Ossifying Fibroma of Jaw Bones Over a Period of 10 Years with Literature Review.10年颌骨骨化性纤维瘤回顾性分析并文献复习
J Maxillofac Oral Surg. 2014 Dec;13(4):560-7. doi: 10.1007/s12663-013-0545-0. Epub 2013 Jun 16.
9
Benign fibro-osseous lesions of the maxillas: analysis of 11 cases.上颌骨的良性纤维-骨病变:11例分析。
Med Oral Patol Oral Cir Bucal. 2008 Oct 1;13(10):E653-6.
10
Fibrous histiocytoma (fibroxanthoma) of a cervical vertebra. A report with a review of the literature.颈椎纤维组织细胞瘤(纤维黄色瘤)。附文献复习报告。
Skeletal Radiol. 1980;5(4):241-6. doi: 10.1007/BF00580597.

引用本文的文献

1
Pathological fractures in the paediatric orthopaedic patient population: a current concepts overview of assessment and management.儿科骨科患者群体中的病理性骨折:评估与管理的当前概念概述
Eur J Orthop Surg Traumatol. 2025 Apr 25;35(1):166. doi: 10.1007/s00590-025-04272-x.
2
Are Fibrous Cortical Defects (FCDs) and Non-Ossifying Fibromas (NOFs) Only Radiological Findings? The Relationship between Radiological/Clinical Findings and Physical Activity in Children and Adolescents: A Cross-Sectional Study.纤维性骨皮质缺损(FCDs)和非骨化性纤维瘤(NOFs)仅是影像学表现吗?儿童和青少年影像学/临床发现与身体活动之间的关系:一项横断面研究。
J Clin Med. 2024 Sep 27;13(19):5751. doi: 10.3390/jcm13195751.
3

本文引用的文献

1
Pitfalls in MR image interpretation prompting referrals to an orthopedic oncology clinic.磁共振成像解读中的陷阱促使患者转诊至骨肿瘤诊所。
Radiographics. 2007 May-Jun;27(3):805-26; discussion 827-8. doi: 10.1148/rg.273065031.
2
On fibrous defects in cortical walls of growing tubular bones: their radiologic appearance, structure, prevalence, natural course, and diagnostic significance.关于生长中管状骨皮质壁的纤维性缺损:其放射学表现、结构、发生率、自然病程及诊断意义。
Adv Pediatr. 1955;7:13-51.
3
Xanthoma of bone: first sign of hyperlipidemia type IIB: a case report.
Jaffe-Campanacci syndrome; a case series and review of the literature.
杰斐-坎帕纳奇综合征;病例系列及文献复习。
BMC Musculoskelet Disord. 2024 Jun 27;25(1):502. doi: 10.1186/s12891-024-07581-0.
4
Nonossifying fibroma of the lower femur with genu valgum: a case report.股骨下段非骨化性纤维瘤合并膝内翻:1 例报告。
BMC Pediatr. 2023 Oct 23;23(1):527. doi: 10.1186/s12887-023-04224-6.
5
An unusually aggressive multiple non-ossifying fibroma of the distal tibia and fibula: A case report.一例罕见的胫骨远端和腓骨侵袭性多发性非骨化性纤维瘤:病例报告
Bone Rep. 2023 Oct 11;19:101721. doi: 10.1016/j.bonr.2023.101721. eCollection 2023 Dec.
6
Musculoskeletal pitfalls in Ga-PSMA PET/CT.镓-前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描(Ga-PSMA PET/CT)中的肌肉骨骼陷阱
Radiol Bras. 2023 Jul-Aug;56(4):220-225. doi: 10.1590/0100-3984.2023.0003.
7
Comparison of MRI Findings among Osteofibrous Dysplasia, Fibrous Dysplasia, and NonOssifying Fibroma of the Long Bone.长骨骨纤维异常增殖症、骨纤维结构不良和非骨化性纤维瘤的MRI表现比较。
Indian J Radiol Imaging. 2023 Jan 13;33(2):150-156. doi: 10.1055/s-0042-1760363. eCollection 2023 Apr.
8
Edema-like marrow signal intensity (ELMSI) associated with nonossifying fibroma (NOF) on MRI: an uncommon finding in a common bone lesion.MRI 上伴发非骨化性纤维瘤(NOF)的类似水肿样骨髓信号强度(ELMSI):一种常见骨病变中的不常见表现。
Skeletal Radiol. 2023 Aug;52(8):1511-1518. doi: 10.1007/s00256-023-04312-9. Epub 2023 Mar 3.
9
Benign incidental do-not-touch bone lesions.良性偶然勿触骨病变。
Br J Radiol. 2023 Feb;96(1142):20211334. doi: 10.1259/bjr.20211334. Epub 2022 May 31.
10
Imaging of Non-ossifying Fibromas: A Case Series.非骨化性纤维瘤的影像学表现:病例系列
Cureus. 2021 Mar 25;13(3):e14102. doi: 10.7759/cureus.14102.
骨黄瘤:IIB型高脂血症的首发体征:病例报告
Clin Orthop Relat Res. 2003 May(410):274-7. doi: 10.1097/01.blo.0000063790.32430.10.
4
Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations.174例有皮肤及皮肤外表现的青少年黄色肉芽肿的临床病理研究:发病年龄在20岁以内者
Am J Surg Pathol. 2003 May;27(5):579-93. doi: 10.1097/00000478-200305000-00003.
5
Fibrous lesions of bone.
Radiol Clin North Am. 1993 Mar;31(2):279-97.
6
The variable bone scan appearances of nonosteogenic fibroma of bone.骨非骨化性纤维瘤的骨扫描表现多样。
Clin Nucl Med. 1981 Jun;6(6):242-5. doi: 10.1097/00003072-198106000-00002.
7
Multiple non-ossifying fibromata with extraskeletal anomalies: a new syndrome?
J Bone Joint Surg Br. 1983 Nov;65(5):627-32. doi: 10.1302/0301-620X.65B5.6643569.
8
Fibrous cortical defect and nonossifying fibroma of bone. A study of the ultrastructure.骨纤维皮质缺损与非骨化性纤维瘤。超微结构研究。
Arch Pathol. 1974 Apr;97(4):205-10.
9
Hypophosphatemic osteomalacia associated with "nonendocrine" tumors.与“非内分泌”肿瘤相关的低磷性骨软化症
N Engl J Med. 1970 Jul 9;283(2):65-70. doi: 10.1056/NEJM197007092830204.
10
Multiple skeletal fibroxanthomas: radiologic-pathologic correlation of 72 cases.
Skeletal Radiol. 1987;16(5):353-9. doi: 10.1007/BF00350960.