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Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 1-Primary Immunodeficiencies.心血管疾病患者的管理应包括对原发性和继发性免疫缺陷的评估：第1部分——原发性免疫缺陷。
Healthcare (Basel). 2024 Oct 4;12(19):1976. doi: 10.3390/healthcare12191976.
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Healthcare (Basel). 2024 Oct 4;12(19):1977. doi: 10.3390/healthcare12191977.
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本文引用的文献

1
Trial of Cardiovascular Risk Factor Assessment and Transthoracic Echocardiography Results in Patients with Primary Antibody Deficiency.原发性抗体缺陷患者心血管风险因素评估和经胸超声心动图结果的临床试验。
Iran J Allergy Asthma Immunol. 2024 Apr 7;23(2):168-181. doi: 10.18502/ijaai.v23i2.15323.
2
Patients with STAT1 Gain-of-function Mutations Display Increased Apoptosis which is Reversed by the JAK Inhibitor Ruxolitinib.STAT1 功能获得性突变患者表现出凋亡增加，而 JAK 抑制剂芦可替尼可逆转这一现象。
J Clin Immunol. 2024 Apr 5;44(4):85. doi: 10.1007/s10875-024-01684-y.
3
Cardiac involvement in the catastrophic antiphospholipid syndrome (CAPS): Lessons from the "CAPS registry".灾难性抗磷脂综合征（CAPS）中的心脏受累：来自“CAPS 登记处”的经验教训。
Semin Arthritis Rheum. 2024 Jun;66:152439. doi: 10.1016/j.semarthrit.2024.152439. Epub 2024 Mar 26.
4
Inborn errors of immunity in adulthood.成人期遗传性免疫缺陷病。
Allergy Asthma Clin Immunol. 2024 Jan 17;20(1):6. doi: 10.1186/s13223-023-00862-8.
5
Common variable immunodeficiency-an independent risk factor for atherosclerotic cardiovascular diseases.普通可变免疫缺陷——动脉粥样硬化性心血管疾病的独立危险因素。
Front Cardiovasc Med. 2023 Nov 8;10:1289675. doi: 10.3389/fcvm.2023.1289675. eCollection 2023.
6
Points to Consider in Health Assessment of Adult Patients with Primary Antibody Deficiencies.原发性抗体缺陷成年患者健康评估中的注意事项。
J Clin Med. 2023 Sep 17;12(18):6018. doi: 10.3390/jcm12186018.
7
Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency.开发一种用于早期检测原发性抗体缺陷风险患者的初级保健筛查算法。
Allergy Asthma Clin Immunol. 2023 May 27;19(1):44. doi: 10.1186/s13223-023-00790-7.
8
Extended List of Warning Signs in Qualification to Diagnosis and Treatment of Inborn Errors of Immunity in Children and Young Adults.儿童和青年先天性免疫缺陷诊断与治疗资质中的扩展警示信号清单。
J Clin Med. 2023 May 11;12(10):3401. doi: 10.3390/jcm12103401.
9
Organ-based clues for diagnosis of inborn errors of immunity: A practical guide for clinicians.基于器官的免疫缺陷病诊断线索：临床医生实用指南。
Immun Inflamm Dis. 2023 Apr;11(4):e833. doi: 10.1002/iid3.833.
10
Case report: Myocarditis in congenital STAT1 gain-of function.病例报告：先天性 STAT1 功能获得性心肌炎。
Front Immunol. 2023 Mar 20;14:1095595. doi: 10.3389/fimmu.2023.1095595. eCollection 2023.

心血管疾病患者的管理应包括对原发性和继发性免疫缺陷的评估：第1部分——原发性免疫缺陷。

Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 1-Primary Immunodeficiencies.

作者信息

Napiórkowska-Baran Katarzyna, Doligalska Agata, Drozd Magdalena, Czarnowska Marta, Łaszczych Dariusz, Dolina Marcin, Szymczak Bartłomiej, Schmidt Oskar, Bartuzi Zbigniew

机构信息

Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Torun, 85-067 Bydgoszcz, Poland.

Student Research Club of Clinical Immunology, Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Torun, 85-067 Bydgoszcz, Poland.

出版信息

Healthcare (Basel). 2024 Oct 4;12(19):1976. doi: 10.3390/healthcare12191976.

DOI:10.3390/healthcare12191976
PMID:39408156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476293/
Abstract

BACKGROUND

Cardiovascular diseases are some of the most prevalent chronic diseases that generate not only high social but also economic costs. It is becoming increasingly crucial to take into account inborn errors of immunity (IEIs, formerly known as primary immunodeficiencies (PIDs)) and secondary immunodeficiencies (SIDs) in the diagnostic and therapeutic management of cardiac patients. The number of diseases classified as IEIs is on the rise, with a current total of 485. It is essential to pay attention not only to already confirmed conditions but also to symptoms suggestive of immunodeficiencies.

OBJECTIVES

The aim of this article is to present IEIs with cardiovascular symptoms that may cause or exacerbate cardiovascular disease, as well as diagnostic and therapeutic procedures.

RESULTS

It is becoming increasingly evident that immunodeficiencies can be responsible for certain cardiovascular conditions, their hastened progression, and difficulties in their control.

CONCLUSIONS

Early detection of deficiencies improves not only the quality and longevity of patients, but also allows for better control of cardiovascular diseases and even prevention of their occurrence.

摘要

背景

心血管疾病是一些最常见的慢性疾病，不仅会产生高昂的社会成本，还会带来经济成本。在心脏病患者的诊断和治疗管理中，考虑先天性免疫缺陷（IEIs，以前称为原发性免疫缺陷（PIDs））和继发性免疫缺陷（SIDs）变得越来越重要。被归类为IEIs的疾病数量正在增加，目前总数为485种。不仅要关注已确诊的疾病，还要关注提示免疫缺陷的症状。

目的

本文旨在介绍可能导致或加重心血管疾病的具有心血管症状的IEIs，以及诊断和治疗程序。

结果

越来越明显的是，免疫缺陷可能导致某些心血管疾病、其加速进展以及控制困难。

结论

早期发现缺陷不仅可以提高患者的生活质量和寿命，还可以更好地控制心血管疾病，甚至预防其发生。