特级初榨橄榄油可降低女性而非男性非酒精性脂肪性肝病的风险：NUTRIHEP 队列研究结果。
Extra Virgin Olive Oil Reduces the Risk of Non-Alcoholic Fatty Liver Disease in Females but Not in Males: Results from the NUTRIHEP Cohort.
机构信息
National Institute of Gastroenterology-IRCCS "Saverio de Bellis", 70013 Castellana Grotte, Italy.
Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
出版信息
Nutrients. 2024 Sep 24;16(19):3234. doi: 10.3390/nu16193234.
BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. One way to resolve this reversible condition is by making dietary changes. Extra virgin olive oil (EVOO) is often associated with an improvement in this disease. The aim of this study was to explore the protective role of EVOO on NAFLD conditions, stratified by gender.
METHODS
The study cohort included 1426 participants assessed in the second recall of the NUTRIHEP cohort (2014-2018), subdivided by gender and dividing the EVOO intake into quartiles of daily gram intake.
RESULTS
The results indicated a protective role of the last quartile of EVOO only for female subjects, OR = 0.43, = 0.02, 0.21 to 0.85 at 95% C.I., whereas in the male sub-cohort, the effect was not statistically significant.
CONCLUSIONS
The protective role of EVOO is different between genders. This difference has not been explored in the literature, so we conclude that this is one of the few papers in the literature to evaluate a gender difference in the intestinal absorption of humans based on an epidemiological study.
背景
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病。通过改变饮食来解决这种可逆转的疾病是一种方法。特级初榨橄榄油（EVOO）通常与改善这种疾病有关。本研究旨在探讨 EVOO 对 NAFLD 状况的保护作用，并按性别进行分层。
方法
研究队列包括在 NUTRIHEP 队列的第二次随访中评估的 1426 名参与者（2014-2018 年），按性别细分，并将 EVOO 摄入量分为每日克摄入量的四分位数。
结果
结果表明，最后一个 EVOO 四分位数仅对女性受试者具有保护作用，OR = 0.43，95%置信区间为 0.02、0.21 至 0.85，而在男性亚组中，效果不具有统计学意义。
结论
EVOO 的保护作用在性别之间存在差异。这一差异在文献中尚未得到探讨，因此我们得出结论，这是为数不多的几篇基于流行病学研究评估人类肠道吸收存在性别差异的文献之一。
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