Department of Biostructure and Animal Physiology, Wroclaw University of Environmental and Life Sciences, Norwida 25/27, 50-375 Wroclaw, Poland.
Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Nutrients. 2024 Sep 30;16(19):3316. doi: 10.3390/nu16193316.
This study investigated the anticancer potential of an aqueous extract of the fungus . The study assessed the effect of the extract on nine cancer cell lines, including melanoma (LM-MEL-75), lung cancer (A549), and colorectal cancer (HT29, LoVo), and four normal cell lines. The cytotoxicity of the extract was evaluated using MTT, sulforhodamine-B (SRB), and clonogenic viability assays. Additionally, the study examined the effect of the extract on plant model organisms, garden cress () and common onion (Allium cepa), to further investigate its biological activity. The assays demonstrated selective cytotoxicity of the extract toward cancer cells, while sparing normal cells. The extract induced significant cytotoxic effects at lower concentrations in lung cancer, melanoma, and colon cancer cells, showing promise as a potential anticancer agent. The results also revealed that the extract inhibited seed germination and root growth, suggesting its potential to disrupt cell cycles and induce apoptosis. This study highlights the therapeutic potential of and highlights the need for further research to identify the active ingredients and mechanisms underlying its anticancer effects.
本研究调查了真菌的水提物的抗癌潜力。该研究评估了提取物对包括黑色素瘤（LM-MEL-75）、肺癌（A549）和结直肠癌（HT29、LoVo）在内的 9 种癌细胞系和 4 种正常细胞系的影响。使用 MTT、磺酰罗丹明 B（SRB）和集落形成活力测定法评估提取物的细胞毒性。此外，该研究还研究了提取物对植物模型生物（荠菜（）和普通洋葱（Allium cepa））的影响，以进一步研究其生物活性。 这些测定表明，提取物对癌细胞具有选择性细胞毒性，而对正常细胞则没有毒性。提取物在较低浓度下对肺癌、黑色素瘤和结肠癌细胞产生显著的细胞毒性作用，表明其具有作为潜在抗癌剂的潜力。结果还表明，提取物抑制了种子的萌发和根的生长，表明其有可能干扰细胞周期并诱导细胞凋亡。 本研究强调了 的治疗潜力，并强调需要进一步研究以确定其抗癌作用的活性成分和机制。
