Laboratory of Applied Neurosciences, Evangelical University of Goiás, UniEvangélica, Av. Universitária S/N, Anápolis P.O. Box 75083-515, GO, Brazil.
Laboratory of Biophotonics and Experimental Therapeutics, LABITEX, Evangelical University of Goiás, UniEvangélica, Av. Universitária S/N, Anápolis P.O. Box 75083-515, GO, Brazil.
Nutrients. 2024 Oct 8;16(19):3403. doi: 10.3390/nu16193403.
BACKGROUND/OBJECTIVES: The oral administration of hydrolyzed collagen peptides is a scientifically validated intervention for enhancing skeletal muscle health and performance. This integrative review consolidates the evidence supporting the use of low molecular weight collagen peptides (2000-3500 daltons) for their superior bioavailability and absorption. Our objective was to review the effects of collagen peptide or hydrolyzed collagen supplementation on muscle damage, recovery, and construction related to physical exercise.
A bibliographic search was conducted in major English-language databases, including PubMed/Medline, using terms like "Peptides Collagen and Damage" and "collagen peptides AND Soreness Muscle". This review followed PRISMA guidelines, with bias risk assessed via the PEDro scale. The inclusion criteria were (a) randomized clinical trials, (b) randomized studies in humans with a control or placebo group, (c) studies assessing muscle damage or delayed onset muscle soreness via physiological markers or strength performance tests, and (d) studies using hydrolyzed collagen or collagen peptides.
Initially, 752 articles were identified. After applying the inclusion and exclusion criteria, including duplicate removal, eight articles with 286 participants were included. Of these, 130 participants received collagen peptide supplementation, while 171 received a placebo or control.
This integrative review supports the potential of collagen peptide supplementation to mitigate muscle stress from acute strenuous resistance training. However, due to the methodological heterogeneity among the studies, further clinical trials are needed to clarify the mechanisms underlying muscle improvement with collagen supplementation.
背景/目的：口服水解胶原蛋白肽是一种经科学验证可增强骨骼肌健康和性能的干预措施。本综述综合了支持使用低分子量胶原蛋白肽（2000-3500 道尔顿）的证据，因为它们具有更高的生物利用度和吸收率。我们的目的是综述胶原蛋白肽或水解胶原蛋白补充对与运动相关的肌肉损伤、恢复和构建的影响。
在主要的英语数据库中进行了文献检索，包括 PubMed/Medline，并使用了“肽胶原和损伤”和“胶原蛋白肽和肌肉酸痛”等术语。本综述遵循 PRISMA 指南，并通过 PEDro 量表评估偏倚风险。纳入标准为：（a）随机临床试验；（b）有对照组或安慰剂组的人类随机研究；（c）通过生理标志物或力量表现测试评估肌肉损伤或迟发性肌肉酸痛的研究；（d）使用水解胶原蛋白或胶原蛋白肽的研究。
最初确定了 752 篇文章。在应用纳入和排除标准（包括重复去除）后，纳入了 8 篇文章，共有 286 名参与者。其中，130 名参与者接受了胶原蛋白肽补充，而 171 名参与者接受了安慰剂或对照。
本综述支持胶原蛋白肽补充剂减轻急性剧烈抗阻训练引起的肌肉应激的潜力。然而，由于研究之间存在方法学异质性，需要进一步的临床试验来阐明胶原蛋白补充改善肌肉的机制。
