Huston J P, Joosten M, Tomaz C
Exp Neurol. 1986 Jan;91(1):147-53. doi: 10.1016/0014-4886(86)90032-4.
Avoidance learning followed by reversal learning was tested in rats after removal of all telencephalic brain structures. In phase I, 24 h after ablation of the telencephalon, rats were given a learning trial in the up-hill avoidance task and tested for retention 2 h later. The animals receiving a tail-shock contingent on the up-hill response showed significant increases in step-up latencies in comparison with control animals that had received noncontingent shock. In phase II, rats of the "reversal learning" group received a tail-shock if they did not perform the up-hill response within 5 s. Control animals received either another up-hill contingent shock or no shock. Two hours later the "reversal" group animals showed a decrement in step-up latencies in comparison with control animals, suggesting that reversal learning of the up-hill avoidance task is possible in rats devoid of the telencephalon.
在切除所有端脑脑结构后，对大鼠进行了回避学习后接着进行反转学习的测试。在第一阶段，端脑切除24小时后，让大鼠在爬坡回避任务中进行一次学习试验，并在2小时后测试记忆保持情况。与接受非条件性电击的对照动物相比，因爬坡反应而接受尾部电击的动物在爬坡潜伏期上有显著增加。在第二阶段，如果“反转学习”组的大鼠在5秒内未做出爬坡反应，就会接受尾部电击。对照动物要么接受另一次与爬坡相关的电击，要么不接受电击。两小时后，与对照动物相比，“反转”组动物的爬坡潜伏期缩短，这表明在没有端脑的大鼠中，爬坡回避任务的反转学习是可能的。
