Huston J P, Tomaz C, Fix I
Behav Brain Res. 1985 Sep-Oct;17(2):87-95. doi: 10.1016/0166-4328(85)90021-x.
Two experiments were undertaken to investigate whether learning of an inhibitory avoidance response is possible in rats devoid of the whole forebrain, except for the hypothalamus. In experiment I all telencephalic structures were surgically ablated. Twenty-four hours later the rats were given a learning trial in the up-hill avoidance task. When tested 2 h later, the animals given a tail-shock contingent on the up-hill response showed significant increases in step-up latencies in comparison with control groups that had received non-contingent shock or no shock. In experiment II the thalamus was removed in addition to the telencephalon. As in experiment I, the animals received either tail-shock contingent on the up-hill reaction, no tail-shock, or non-contingent shock. When tested 2 and 24 h after the training, the animals that had received response-contingent shock showed significant increases in latencies to ascend the platform. These results indicate that inhibitory avoidance conditioning is still possible in rats devoid of the telencephalon plus thalamus.
进行了两项实验，以研究除下丘脑外整个前脑缺失的大鼠是否有可能学习抑制性回避反应。在实验I中，所有端脑结构均通过手术切除。24小时后，大鼠接受了上坡回避任务的学习试验。2小时后进行测试时，与接受非条件电击或未电击的对照组相比，因上坡反应而接受尾部电击的动物在踏上平台的潜伏期上有显著增加。在实验II中，除端脑外还切除了丘脑。与实验I一样，动物接受因上坡反应而产生的尾部电击、无尾部电击或非条件电击。在训练后2小时和24小时进行测试时，接受条件电击的动物在登上平台的潜伏期上有显著增加。这些结果表明，在端脑加丘脑缺失的大鼠中，抑制性回避条件反射仍然是可能的。
