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富含维生素 C 的水凝胶敷料生物材料：合成与表征。

Hydrogel Dressing Biomaterial Enriched with Vitamin C: Synthesis and Characterization.

机构信息

Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Krakow, Al. Mickiewicza 30, 30-059 Krakow, Poland.

Department of Animal Biotechnology, Faculty of Animal Science, University of Agriculture in Krakow, Al. Mickiewicza 24/28, 31-059 Krakow, Poland.

出版信息

Int J Mol Sci. 2024 Sep 30;25(19):10565. doi: 10.3390/ijms251910565.

DOI:10.3390/ijms251910565
PMID:39408893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476569/
Abstract

Materials engineering has become an important tool in the field of hydrogel dressings used to treat difficult-to-heal wounds. Hydrogels filled with bioactive substances used as a targeted healing system are worthy of attention. Vitamin C has healing and supporting effects in the treatment of many skin problems. The aim of the research was to produce a hydrogel biomaterial enriched with ascorbic acid for use as a dressing for difficult-to-heal wounds. A total of four different dressings were developed, each with different modifications in each layer. The dressing with vitamin C in the third layer was shown to release vitamin C ions more slowly than the dressing with vitamin C in the first layer. The studies conducted have shown that the dressings containing vitamin C have, among other things, a higher compressive strength, are characterised by a lower relative shortening after the application of force and shorten without damage at a lower force than in the case of a dressing without vitamin C. The dressings designed have a very good stability in the temperature range of 18 °C to 60 °C. It was found that the higher the vitamin C content in the dressing, the greater the increase in the specific heat value of the transformations. Therefore, hydrogel dressings containing vitamin C may be candidates for local delivery of vitamin C to the skin and protection of the wound area.

摘要

材料工程已成为水凝胶敷料领域的重要工具，可用于治疗难以愈合的伤口。含有生物活性物质的水凝胶可用作靶向愈合系统，值得关注。维生素 C 在治疗许多皮肤问题方面具有愈合和支持作用。本研究的目的是生产富含抗坏血酸的水凝胶生物材料，用作治疗难以愈合的伤口的敷料。共开发了四种不同的敷料，每层都有不同的修饰。与第一层含有维生素 C 的敷料相比，第三层含有维生素 C 的敷料释放维生素 C 离子的速度更慢。进行的研究表明，含有维生素 C 的敷料除其他外具有更高的抗压强度、在施加力后相对缩短率较低、在低于不含有维生素 C 的敷料的力下损坏而缩短。设计的敷料在 18°C 至 60°C 的温度范围内具有非常好的稳定性。结果发现，敷料中维生素 C 的含量越高，相变的比热值增加越大。因此，含有维生素 C 的水凝胶敷料可能是局部向皮肤输送维生素 C 和保护伤口区域的候选物。

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