Su Jingjing, Li Jiankang, Liang Jiaheng, Zhang Kun, Li Jingan
School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
School of Materials Science and Engineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China.
Life (Basel). 2021 Sep 27;11(10):1016. doi: 10.3390/life11101016.
Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moist environment for wound repair, which overcomes the shortcomings of traditional dressings. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.
伤口已成为全球范围内的死亡原因之一。伤口微环境的代谢紊乱会导致一系列严重症状，尤其是慢性伤口给患者带来巨大痛苦，且目前尚无有效且广泛应用的伤口敷料。因此，开发新型多功能伤口敷料具有重要意义。水凝胶因其三维结构、良好的渗透性、出色的生物相容性以及为伤口修复提供湿润环境的能力，成为理想的敷料候选材料，克服了传统敷料的缺点。本文首先简要介绍皮肤伤口愈合过程，接着介绍水凝胶敷料的制备方法以及由天然生物材料和合成材料制成的水凝胶伤口敷料的特点。最后，探讨水凝胶伤口敷料的发展前景与挑战。
