Prete Sabrina, Dattilo Marco, Patitucci Francesco, Pezzi Giuseppe, Parisi Ortensia Ilaria, Puoci Francesco
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
J Funct Biomater. 2023 Sep 3;14(9):455. doi: 10.3390/jfb14090455.
Biomaterials are at the forefront of the future, finding a variety of applications in the biomedical field, especially in wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try to heal through a series of interconnected processes involving several initiators and mediators such as cytokines, macrophages, and fibroblasts. The combination of biopolymers with wound healing properties may provide opportunities to synthesize matrices that stimulate and trigger target cell responses crucial to the healing process. This review outlines the optimal management and care required for wound treatment with a special focus on biopolymers, drug-delivery systems, and nanotechnologies used for enhanced wound healing applications. Researchers have utilized a range of techniques to produce wound dressings, leading to products with different characteristics. Each method comes with its unique strengths and limitations, which are important to consider. The future trajectory in wound dressing advancement should prioritize economical and eco-friendly methodologies, along with improving the efficacy of constituent materials. The aim of this work is to give researchers the possibility to evaluate the proper materials for wound dressing preparation and to better understand the optimal synthesis conditions as well as the most effective bioactive molecules to load.
生物材料处于未来发展的前沿，由于其生物相容性和可生物降解性，在生物医学领域有着广泛的应用，尤其是在伤口愈合方面。伤口会通过一系列相互关联的过程自发愈合，这些过程涉及多种启动因子和介质，如细胞因子、巨噬细胞和成纤维细胞。具有伤口愈合特性的生物聚合物的组合可能为合成刺激和触发对愈合过程至关重要的靶细胞反应的基质提供机会。本综述概述了伤口治疗所需的最佳管理和护理，特别关注用于增强伤口愈合应用的生物聚合物、药物递送系统和纳米技术。研究人员利用了一系列技术来生产伤口敷料，从而得到了具有不同特性的产品。每种方法都有其独特的优点和局限性，这些都值得考虑。伤口敷料未来的发展方向应优先考虑经济和环保的方法，同时提高组成材料的功效。这项工作的目的是让研究人员能够评估用于制备伤口敷料的合适材料，更好地理解最佳合成条件以及要负载的最有效的生物活性分子。
