School of Chemistry and Chemical Engineering, Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province , Gannan Normal University , Ganzhou , 341000 , China.
ACS Sens. 2019 Apr 26;4(4):782-791. doi: 10.1021/acssensors.9b00438. Epub 2019 Apr 4.
Noble metal nanoparticle-based colorimetric sensors have become powerful tools for the detection of different targets with convenient readout. Among the many types of nanomaterials, noble metal nanoparticles exhibit extraordinary optical responses mainly due to their excellent localized surface plasmon resonance (LSPR) properties. The absorption spectrum of the noble metal nanoparticles was mostly in the visible range. This property enables the visual detection of various analytes with the naked eye. Among numerous color change modes, the way that different concentrations of targets represent vivid color changes has been brought to the forefront because the color distinction capability of normal human eyes is usually better than the intensity change capability. We review the state of the art in noble metal nanoparticle-based multicolor colorimetric strategies adopted for visual quantification by the naked eye. These multicolor strategies based on different means of morphology transformation are classified into two categories, namely, the etching of nanoparticles and the growth of nanoparticles. We highlight recent progress on the different means by which biocatalytic reactions mediated LSPR modulation signal generation and their applications in the construction of multicolor immunoassays. We also discuss the current challenges associated with multicolor colorimetric sensors during actual sample detection and propose the future development of next-generation multicolor qualification strategies.
基于贵金属纳米粒子的比色传感器已成为用于检测不同目标物的有力工具，具有便捷的读取功能。在众多纳米材料中，贵金属纳米粒子由于其出色的局域表面等离子体共振（LSPR）特性，表现出非凡的光学响应。贵金属纳米粒子的吸收光谱主要在可见光范围内。这种特性使各种分析物能够通过肉眼进行可视化检测。在众多颜色变化模式中，由于正常人眼的颜色分辨能力通常优于强度变化能力，因此不同浓度的目标物呈现出鲜明颜色变化的方式成为了研究热点。我们综述了基于贵金属纳米粒子的比色策略在通过肉眼进行可视化定量方面的最新进展。这些基于不同形态转变手段的多色策略可分为两类，即纳米粒子的刻蚀和纳米粒子的生长。我们重点介绍了生物催化反应介导的 LSPR 调制信号产生的不同方式在多色免疫分析构建中的最新进展及其应用。我们还讨论了在实际样品检测中多色比色传感器所面临的当前挑战，并提出了下一代多色定量策略的未来发展方向。
