结直肠癌分期迁移的发生率与动态变化：区域分析与全国分析
Incidence and Dynamics of CRC Stage Migration: A Regional vs. a National Analysis.
作者信息
Faris Carol, Cuaranta Araceli, Abdelmasseh Michael, Finley Rob, Payne Barbara, Gorka Alexei, Sanabria Juan
机构信息
Department of Surgery, Marshall University School of Medicine (MUSOM), Huntington, WV 25701, USA.
出版信息
Cancers (Basel). 2024 Sep 24;16(19):3245. doi: 10.3390/cancers16193245.
BACKGROUND/OBJECTIVES: Due to an increased rate of surveillance colonoscopy, we aim to determine the impact of stage migration on the incidence and overall survival (OS) of patients who underwent pathological staging of colorectal cancer (CRC) at our Health Network System.
METHODS
Two datasets were included: subjects from the tumor registry at a regional Comprehensive Cancer Center = 1385) and subjects from the Surveillance, Epidemiology, and End Results (SEER) national database ( = 202,391).
RESULTS
A significant increase in the diagnosis of CRC Stage 1 and 4 was observed, with a decrease in stage 2, and no change in Stage 3 in the National datasets ( < 0.01). There was an increase in Stage 4 CRC diagnosis, with a concurrent decrease in stage 2, and no changes in stages 1 and 3 in the regional dataset ( < 0.05). OS followed the expected and progressive decrease in OS by stage (from 1 to 4, < 0.01).
CONCLUSIONS
The present findings confirmed CRC stage migration in our Health Network System, along with a national trend conducive to an increased OS for early CRC stages.
背景/目的：由于监测性结肠镜检查的比例增加，我们旨在确定分期迁移对在我们的健康网络系统中接受结直肠癌（CRC）病理分期的患者的发病率和总生存期（OS）的影响。
方法
纳入了两个数据集：来自区域综合癌症中心肿瘤登记处的受试者（n = 1385）和来自监测、流行病学和最终结果（SEER）国家数据库的受试者（n = 202,391）。
结果
在国家数据集中，观察到CRC 1期和4期的诊断显著增加，2期减少，3期无变化（P < 0.01）。在区域数据集中，4期CRC诊断增加，同时2期减少，1期和3期无变化（P < 0.05）。OS随分期呈预期的逐渐下降（从1期到4期，P < 0.01）。
结论
本研究结果证实了我们健康网络系统中CRC分期的迁移，以及有利于早期CRC分期患者OS增加的全国趋势。
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