Babatunde Oluwole A, Gonzalez Katherine, Osazuwa-Peters Nosayaba, Adams Swann Arp, Hughes Halbert Chanita, Clark Frank, Nagar Anusuiya, Obeysekare Jessica, Adjei Boakye Eric
Department of Psychiatry, Prisma Health, Greer, SC 29650, USA.
School of Medicine, California University of Science and Medicine, Colton, CA 92324, USA.
Cancers (Basel). 2024 Sep 27;16(19):3290. doi: 10.3390/cancers16193290.
Adverse childhood experiences (ACEs) are linked to a heightened risk of depression. We explored the relationship between ACEs and both depression and mental distress among cancer survivors. This was a cross-sectional analysis using the 2022 Behavioral Risk Factor Surveillance System database of cancer survivors aged ≥18 (n = 14,132). The primary outcome was self-reported history of depression, and the secondary outcome was mental distress. The exposure variable was the number of ACEs, classified as 0, 1-2, and ≥3. Weighted multivariable logistic regression models assessed the association between the number of ACEs and depression and mental distress while adjusting for covariates. Approximately 22% of respondents reported experiencing ≥3 ACEs. The prevalence of depression was 21.8%, and mental distress was 15.4%. Compared with cancer survivors who had experienced 0 ACEs, those who had experienced ≥3 (aOR = 3.94; 95% CI, 3.04-5.10) or 1-2 (aOR = 1.85; 95% CI, 1.47-2.32) ACEs had a higher likelihood of reporting depression. Compared with cancer survivors who had experienced 0 ACEs, those who had experienced ≥3 (aOR = 0.67; 95% CI, 0.48-0.93) had a lower likelihood of reporting mental distress. This study highlights the impact of ACEs on depression in adulthood among cancer survivors.
童年不良经历（ACEs）与患抑郁症的风险增加有关。我们探讨了癌症幸存者中ACEs与抑郁症和心理困扰之间的关系。这是一项横断面分析，使用了2022年行为风险因素监测系统中年龄≥18岁的癌症幸存者数据库（n = 14,132）。主要结局是自我报告的抑郁症病史，次要结局是心理困扰。暴露变量是ACEs的数量，分为0、1 - 2和≥3。加权多变量逻辑回归模型在调整协变量的同时评估了ACEs数量与抑郁症和心理困扰之间的关联。约22%的受访者报告经历过≥3次ACEs。抑郁症的患病率为21.8%，心理困扰的患病率为15.4%。与经历过0次ACEs的癌症幸存者相比，经历过≥3次（调整后比值比[aOR] = 3.94；95%置信区间[CI]，3.04 - 5.10）或1 - 2次（aOR = 1.85；95% CI，1.47 - 2.32）ACEs的幸存者报告患抑郁症的可能性更高。与经历过0次ACEs的癌症幸存者相比，经历过≥3次（aOR = 0.67；95% CI，0.48 - 0.93）的幸存者报告心理困扰的可能性更低。这项研究突出了ACEs对成年癌症幸存者抑郁症的影响。
