Burford-Eyre Samuel, Aitkenhead Adam, Aylward Jack D, Henthorn Nicholas T, Ingram Samuel P, Mackay Ranald, Manger Samuel, Merchant Michael J, Sitch Peter, Warmenhoven John-William, Appleby Robert B
Department of Physics and Astronomy and the Cockcroft Institute, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, UK.
Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester M20 4BX, UK.
Cancers (Basel). 2024 Sep 27;16(19):3315. doi: 10.3390/cancers16193315.
: To evaluate and compare the deliverability of 'sawtooth' proton arc therapy (PAT) plans relative to static intensity modulated proton therapy (IMPT) at a cyclotron-based clinical facility. : The delivery of single and dual arc Sawtooth PAT plans for an abdominal CT phantom and multiple clinical cases of brain, head and neck (H&N) and base of skull (BoS) targets was emulated under the step-and-shoot and continuous PAT delivery regimes and compared to that of a corresponding static IMPT plan. : Continuous PAT delivery increased the time associated with beam delivery and gantry movement in single/dual PAT plans by 4.86/7.34 min (brain), 7.51/12.40 min (BoS) and 6.59/10.57 min (H&N) on average relative to static IMPT. Step-and-shoot PAT increased this delivery time further by 4.79 min on average as the delivery was limited by gantry motion. : The emulator can approximately model clinical sawtooth PAT delivery but requires experimental validation. No clear benefit was observed regarding beam-on time for sawtooth PAT relative to static IMPT.
在基于回旋加速器的临床机构中,评估并比较“锯齿”质子弧光治疗(PAT)计划相对于静态调强质子治疗(IMPT)的可交付性。在步进式和连续PAT交付模式下,模拟腹部CT体模以及脑、头颈部(H&N)和颅底(BoS)靶区的多个临床病例的单弧和双弧锯齿PAT计划的交付,并与相应的静态IMPT计划进行比较。相对于静态IMPT,连续PAT交付使单/双PAT计划中与束流交付和机架运动相关的时间平均增加了4.86/7.34分钟(脑)、7.51/12.40分钟(BoS)和6.59/10.57分钟(H&N)。由于交付受机架运动限制,步进式PAT使该交付时间平均进一步增加4.79分钟。该模拟器可以大致模拟临床锯齿PAT交付,但需要实验验证。相对于静态IMPT,未观察到锯齿PAT在束流开启时间方面有明显优势。