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基于RGD的自组装纳米药物用于改善肿瘤治疗。

RGD-based self-assembling nanodrugs for improved tumor therapy.

作者信息

Wang Bin, Tang Dongmei, Cui Jianqiao, Jiang Hongfei, Yu Jing, Guo Zhu

机构信息

Department of Sports Medicine, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

出版信息

Front Pharmacol. 2024 Oct 1;15:1477409. doi: 10.3389/fphar.2024.1477409. eCollection 2024.

DOI:10.3389/fphar.2024.1477409
PMID:39411070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11473307/
Abstract

RGD-based self-assembling nanodrugs are a promising advancement in targeted cancer therapy, combining the specificity of RGD peptides with the benefits of nanotechnology. These nanodrugs enhance tumor targeting and cellular uptake while reducing off-target effects. RGD peptides facilitate the self-assembly of stable nanostructures, ensuring efficient drug delivery. Despite their potential, challenges such as immunogenicity, stability, tumor heterogeneity, and manufacturing scalability need to be addressed. Future research should focus on improving biocompatibility, advanced targeting strategies, personalized medicine approaches, and innovative manufacturing techniques. Overcoming these challenges will pave the way for the successful clinical translation of RGD-based nanodrugs, offering more effective and safer cancer treatments.

摘要

基于RGD的自组装纳米药物是靶向癌症治疗领域一项很有前景的进展，它将RGD肽的特异性与纳米技术的优势相结合。这些纳米药物增强了肿瘤靶向性和细胞摄取，同时减少了脱靶效应。RGD肽促进稳定纳米结构的自组装，确保高效的药物递送。尽管它们具有潜力，但免疫原性、稳定性、肿瘤异质性和制造可扩展性等挑战仍需解决。未来的研究应专注于提高生物相容性、先进的靶向策略、个性化医疗方法和创新的制造技术。克服这些挑战将为基于RGD的纳米药物成功转化为临床应用铺平道路，提供更有效、更安全的癌症治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/3a95d9606953/fphar-15-1477409-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/c02078ba15ac/fphar-15-1477409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/fd31b09f74dc/fphar-15-1477409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/85387abce5ba/fphar-15-1477409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/f745a8c3e7ee/fphar-15-1477409-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/92812621c8a5/fphar-15-1477409-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/03af9f1f6ead/fphar-15-1477409-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/87a0e4015f28/fphar-15-1477409-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/be2284791ddf/fphar-15-1477409-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/3a95d9606953/fphar-15-1477409-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/c02078ba15ac/fphar-15-1477409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/fd31b09f74dc/fphar-15-1477409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/85387abce5ba/fphar-15-1477409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/f745a8c3e7ee/fphar-15-1477409-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/92812621c8a5/fphar-15-1477409-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/03af9f1f6ead/fphar-15-1477409-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/87a0e4015f28/fphar-15-1477409-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/be2284791ddf/fphar-15-1477409-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e99e/11473307/3a95d9606953/fphar-15-1477409-g009.jpg

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Pharmaceutics. 2024 Jul 31;16(8):1017. doi: 10.3390/pharmaceutics16081017.
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Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment.用于癌症治疗的刺激响应性小分子前药的开发策略。
Front Pharmacol. 2024 Jul 31;15:1434137. doi: 10.3389/fphar.2024.1434137. eCollection 2024.
3
The advancements and prospective developments in anti-tumor targeted therapy.
Biomark Res. 2025 Mar 5;13(1):38. doi: 10.1186/s40364-025-00745-7.
抗肿瘤靶向治疗的进展和展望。
Neoplasia. 2024 Oct;56:101024. doi: 10.1016/j.neo.2024.101024. Epub 2024 Jul 23.
4
Exploring treatment options in cancer: Tumor treatment strategies.探索癌症的治疗选择：肿瘤治疗策略。
Signal Transduct Target Ther. 2024 Jul 17;9(1):175. doi: 10.1038/s41392-024-01856-7.
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Self-Assembled Nanocomposite DOX/TPOR@CB[7] for Enhanced Synergistic Photodynamic Therapy and Chemotherapy in Neuroblastoma.用于增强神经母细胞瘤协同光动力疗法和化疗的自组装纳米复合材料DOX/TPOR@CB[7]
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Int J Pharm. 2024 May 25;657:124183. doi: 10.1016/j.ijpharm.2024.124183. Epub 2024 Apr 30.
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