Department of Hematology and Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan Province, PR China.
Department of Breast, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan Province, PR China.
PLoS One. 2024 Oct 16;19(10):e0311094. doi: 10.1371/journal.pone.0311094. eCollection 2024.
Our goal was to assess the impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma (ENKTCL). We searched the SEER database to retrospectively enroll patients with ENKTCL. The effects of cancer history on overall survival (OS) and disease-specific survival (DSS) were analyzed using the Cox model. A total of 691 patients were included, of whom 54 (7.8%) had prior histories of cancer. The most common solid malignancy was bone/soft tissue sarcoma. Most secondary ENKTCL cases occurred within 5-9 years following the first cancer diagnosis. Radiotherapy and chemotherapy had been administered to 45 and 40 patients, respectively, to treat their previous malignancies. Prior cancer history had little impact on DSS; however, the presence of prior solid cancer history, latency period of 10+ years, and prior administration of radiotherapy or chemotherapy significantly decreased OS. Prior cancer history had no effect on DSS, but survival compromised OS under specific circumstances.
我们的目的是评估既往癌症史对结外 NK/T 细胞淋巴瘤（ENKTCL）预后的影响。我们检索 SEER 数据库，回顾性纳入了 ENKTCL 患者。采用 Cox 模型分析癌症史对总生存（OS）和疾病特异性生存（DSS）的影响。共纳入 691 例患者，其中 54 例（7.8%）有既往癌症史。最常见的实体恶性肿瘤是骨/软组织肉瘤。大多数继发性 ENKTCL 病例发生在首次癌症诊断后 5-9 年内。分别有 45 例和 40 例患者接受了放疗和化疗来治疗其先前的恶性肿瘤。既往癌症史对 DSS 的影响较小；然而，存在既往实体瘤病史、潜伏期超过 10 年以及既往放疗或化疗显著降低 OS。既往癌症史对 DSS 无影响，但在特定情况下会影响 OS。
