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极度肥胖者的脂肪细胞在培养中过度增殖。

Excessive proliferation in culture of reverted adipocytes from massively obese persons.

作者信息

Roncari D A, Kindler S, Hollenberg C H

出版信息

Metabolism. 1986 Jan;35(1):1-4. doi: 10.1016/0026-0495(86)90087-9.

DOI:10.1016/0026-0495(86)90087-9
PMID:3941607
Abstract

Differentiated omental adipocytes from lean and massively obese persons lost their spherical shape in culture and regained the ability to replicate. In propagating culture, reverted cells from each group multiplied to a greater extent than corresponding stromal adipocyte precursors. Reverted adipocytes from the massively obese proliferated at significantly higher rates than those from lean subjects. Reverted cells derived from 1-2 adipocytes also revealed these differences.

摘要

来自瘦人和极度肥胖者的分化网膜脂肪细胞在培养中失去了球形形态,并恢复了复制能力。在传代培养中,每组的回复细胞比相应的基质脂肪细胞前体增殖得更多。极度肥胖者的回复脂肪细胞增殖速度明显高于瘦人。来自1-2个脂肪细胞的回复细胞也显示出这些差异。

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Excessive proliferation in culture of reverted adipocytes from massively obese persons.极度肥胖者的脂肪细胞在培养中过度增殖。
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引用本文的文献

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Release of mitogenic factors by cultured preadipocytes from massively obese human subjects.来自极度肥胖人类受试者的培养前脂肪细胞释放促有丝分裂因子。
J Clin Invest. 1987 Feb;79(2):632-6. doi: 10.1172/JCI112859.
2
Exaggerated triglyceride accretion in human preadipocyte-murine renal line hybrids composed of cells from massively obese subjects.在由极度肥胖个体的细胞组成的人前脂肪细胞-小鼠肾系杂交细胞中甘油三酯过度蓄积。
J Clin Invest. 1988 May;81(5):1639-45. doi: 10.1172/JCI113499.
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Adipose tissue development: the role of precursor cells and adipogenic factors. Part I: Adipose tissue development and the role of precursor cells.
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Augmented production of heparin-binding mitogenic proteins by preadipocytes from massively obese persons.极度肥胖者的前脂肪细胞中肝素结合促有丝分裂蛋白的产生增加。
J Clin Invest. 1992 Oct;90(4):1226-31. doi: 10.1172/JCI115984.