Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, The First Hospital of Nanchang Medical College, Nanchang, China.
Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.
Front Immunol. 2022 Feb 24;13:845684. doi: 10.3389/fimmu.2022.845684. eCollection 2022.
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that the intestine is an important potential organ for the excretion of uric acid outside the kidneys. The excretion of uric acid of gut is mainly achieved through the action of uric acid transporters and the catabolism of intestinal flora, which plays an important role in the body's uric acid balance. Here we reviewed the effects of intestinal uric acid transporters and intestinal flora on uric acid excretion, and provide new ideas for the treatment of hyperuricemia and gout.
痛风是一种常见的炎性关节炎，由尿酸钠晶体在关节中的沉积引起。高尿酸血症是痛风的根本因素。高尿酸血症的发病与嘌呤代谢紊乱或尿酸排泄障碍有关。目前的研究表明，肠道是肾脏外尿酸排泄的重要潜在器官。尿酸的肠道排泄主要通过尿酸转运体的作用和肠道菌群的代谢来实现，这在机体尿酸平衡中起着重要作用。本文综述了肠道尿酸转运体和肠道菌群对尿酸排泄的影响，为高尿酸血症和痛风的治疗提供了新的思路。
