Bochkov N P, Filippova T V, Kuzin S M, Stukalov S V
Mutat Res. 1986 Jan-Feb;159(1-2):103-7. doi: 10.1016/0027-5107(86)90118-1.
A comparative study of cytogenetic effects in human lymphocytes caused in vivo by cyclophosphamide (CP) after intravenous injection and in vitro by exposure of plasma of the same patients was carried out. It was found that the frequency of induced chromosome aberrations (CA) and sister-chromatid exchanges (SCE) increased linearly for SCE and exponentially for CA within the 'dose' of alkylating activity of CP metabolites. Parameters of 'cytogenetic effect-dose' in vivo and in vitro coincided. The intensity of cytogenetic effects varied between individuals.
进行了一项比较研究，观察静脉注射环磷酰胺（CP）后在体内以及将相同患者的血浆进行体外暴露时，CP对人淋巴细胞的细胞遗传学效应。结果发现，在CP代谢产物的烷基化活性“剂量”范围内，诱导的染色体畸变（CA）频率呈指数增加，而姐妹染色单体交换（SCE）频率呈线性增加。体内和体外的“细胞遗传学效应-剂量”参数相符。细胞遗传学效应的强度在个体之间存在差异。
