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生姜在化疗患者恶心管理中的作用。

Role of Ginger in management of nausea among patients receiving chemotherapy.

作者信息

Syed Zamin Abbas, Fahim Ammad, Safdar Mahpara, Imtiaz Rafia

机构信息

Zamin Abbas Syed, Principal (Nursing and Midwifery), Health Services Academy, Islamabad, Pakistan.

Ammad Fahim, Director ORIC, Indus Hopsital Health Network, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2024 Oct;40(9):2036-2040. doi: 10.12669/pjms.40.9.8739.

DOI:10.12669/pjms.40.9.8739
PMID:39416604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476162/
Abstract

OBJECTIVE

Cancer patients treated with chemotherapy often face variety of side effects, with nausea and vomiting being the most frequent. Ginger (), contains natural compounds that can speed up the metabolism and increase intestinal motility. It is traditionally used to treat gastrointestinal disorders. The objective of this study was to evaluate the role of ginger in management of nausea among patients receiving chemotherapy.

METHODS

This crossover interventional study was conducted to evaluate the role of ginger in management of nausea among patients receiving chemotherapy. Study was carried out at chemotherapy daycare of Shifa International Hospital Islamabad, with a sample size of 90 patients, using non-probability convenient sampling. Patients undergoing chemotherapy were given the dose of ginger (550 mg twice a day) for five consecutive days. On the next chemo cycle the same patients were given the placebo capsules of same color and weight for two times a day for five days. Patients and attendants were contacted for five days and being asked about post-chemotherapy nausea. Nausea and vomiting were measured by Rhodes scale.

RESULTS

Results showed that Rhodes score of patients taking Ginger capsules was significantly lower than those taking placebo (p-value < 0.05) in all the five days.

CONCLUSION

Ginger significantly managed the nausea among patients receiving chemotherapy. Its natural antiemetic properties provide a convenient and safe way to reduce the post-chemotherapy nausea and vomiting.

摘要

目的

接受化疗的癌症患者常常面临各种副作用，其中恶心和呕吐最为常见。生姜含有能加速新陈代谢和增强肠道蠕动的天然化合物。传统上，生姜用于治疗胃肠道疾病。本研究的目的是评估生姜在接受化疗患者恶心管理中的作用。

方法

本交叉干预研究旨在评估生姜在接受化疗患者恶心管理中的作用。研究在伊斯兰堡希法国际医院化疗日间病房进行，样本量为90例患者，采用非概率方便抽样。接受化疗的患者连续五天服用生姜剂量（550毫克，每日两次）。在下一个化疗周期，给同一批患者服用相同颜色和重量的安慰剂胶囊，每日两次，共五天。在五天内联系患者及其陪护人员，询问化疗后恶心情况。恶心和呕吐通过罗兹量表进行测量。

结果

结果显示，在所有五天中，服用生姜胶囊患者的罗兹评分显著低于服用安慰剂的患者（p值<0.05）。

结论

生姜显著缓解了接受化疗患者的恶心症状。其天然的止吐特性为减轻化疗后恶心和呕吐提供了一种方便且安全的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/11476162/cc40164e0340/PJMS-40-2036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/11476162/cc40164e0340/PJMS-40-2036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e33/11476162/cc40164e0340/PJMS-40-2036-g001.jpg

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本文引用的文献

1
Who Is a Cancer Survivor? A Systematic Review of Published Definitions.谁是癌症幸存者？已发表定义的系统综述
J Cancer Educ. 2017 Jun;32(2):228-237. doi: 10.1007/s13187-016-0997-2.
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Global trends of lung cancer mortality and smoking prevalence.全球肺癌死亡率和吸烟率趋势。
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Can nausea and vomiting be treated with ginger extract?生姜提取物能治疗恶心和呕吐吗？
Eur Rev Med Pharmacol Sci. 2015 Apr;19(7):1291-6.
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Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer.姜及其成分：在预防和治疗胃肠道癌中的作用。
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Prevalence, risk factors and disease knowledge of breast cancer in Pakistan.巴基斯坦乳腺癌的患病率、风险因素及疾病认知情况
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The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy.奥氮平与甲氧氯普胺治疗高致吐性化疗患者化疗突破性恶心和呕吐的比较。
Support Care Cancer. 2013 Jun;21(6):1655-63. doi: 10.1007/s00520-012-1710-6. Epub 2013 Jan 12.
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The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review.生姜治疗妊娠剧吐的有效性和安全性：系统评价。
Women Birth. 2013 Mar;26(1):e26-30. doi: 10.1016/j.wombi.2012.08.001. Epub 2012 Aug 28.
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Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial.生姜对急性和延迟性化疗所致恶心呕吐的影响：一项初步、随机、开放标签临床试验。
Integr Cancer Ther. 2012 Sep;11(3):204-11. doi: 10.1177/1534735411433201. Epub 2012 Feb 7.
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Chemotherapy definitions and policies for thymic malignancies.胸腺恶性肿瘤的化疗定义与政策
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