Langille B L, O'Donnell F
Science. 1986 Jan 24;231(4736):405-7. doi: 10.1126/science.3941904.
A 70 percent reduction in the rate of blood flow through the common carotid artery in rabbits caused a 21 percent decrease in the diameter of this artery within 2 weeks. The smooth muscle relaxant papaverine did not attenuate the response; therefore, such reductions in diameter probably reflect a structural modification of the arterial wall rather than sustained contraction of smooth muscle. This arterial response to reduced blood flow was abolished when the endothelium was removed from the vessels. It appears that the endothelium is essential for the compensatory arterial response to long-term changes in luminal blood flow rates.
家兔颈总动脉血流速率降低70%会导致该动脉直径在2周内减小21%。平滑肌松弛剂罂粟碱并未减弱这种反应；因此，这种直径减小可能反映了动脉壁的结构改变，而非平滑肌的持续收缩。当血管内皮被去除后，这种动脉对血流减少的反应就消失了。看来，内皮对于动脉对管腔血流速率长期变化的代偿性反应至关重要。
