Roos R P, Graves M C, Wollmann R L, Chilcote R R, Nixon J
Neurology. 1981 Oct;31(10):1263-70. doi: 10.1212/wnl.31.10.1263.
An immunosuppressed child with acute lymphoblastic leukemia in clinical remission developed measles inclusion body encephalitis (MIBE). Although measles antigen and nonbudding measles virus nucleocapsids were detected in brain tissue, no virus was isolated. Immune precipitation of measles virus proteins with the patient's serum showed no detectable antibody to virus M protein, a finding that has been reported in subacute sclerosing panencephalitis (SSPE). The virologic and immune precipitation studies suggest a similar virus mutation in MIBE and SSPE. The pathogenesis of the two diseases may also be similar.
一名处于临床缓解期的免疫抑制急性淋巴细胞白血病患儿患上了麻疹包涵体脑炎（MIBE）。尽管在脑组织中检测到了麻疹抗原和非出芽的麻疹病毒核衣壳，但未分离出病毒。用患者血清对麻疹病毒蛋白进行免疫沉淀，结果显示未检测到针对病毒M蛋白的抗体，这一发现曾在亚急性硬化性全脑炎（SSPE）中报道过。病毒学和免疫沉淀研究表明，MIBE和SSPE中存在相似的病毒突变。这两种疾病的发病机制可能也相似。
