Interlandi Claudia, Spadola Filippo, Neve Veronica C, Tabbì Marco, Di Pietro Simona, Giudice Elisabetta, Macrì Daniele, Costa Giovanna L
Department of Veterinary Sciences, University of Messina, Messina, Italy.
Experimental Zooprophylactic Institute of Sicily (IZSSi), Palermo, Italy.
Front Vet Sci. 2024 Oct 3;11:1470957. doi: 10.3389/fvets.2024.1470957. eCollection 2024.
The aim of the study was to compare the analgesic efficacy of butorphanol and lidocaine, alone or in combination, in calves undergoing surgical repair of umbilical hernia. The study was conducted in 60 calves of different breeds. Xylazine 0.3 mg/kg was administered intramuscularly to all animals in the study. The animals were then divided into three groups ( = 20) that received different treatments with lidocaine at 4.5 mg/kg and butorphanol at 0.02 mg/kg. The L group received lidocaine both by infiltration of the surgical planes and intraperitoneally, the B group received butorphanol both by infiltration of the surgical planes and intraperitoneally, and finally the LB group received lidocaine by infiltration of the surgical planes and butorphanol intraperitoneally. Heart and respiratory rates, haemoglobin oxygen saturation, non-invasive blood pressure and temperature were recorded during surgery. Response to the surgical stimulus was scored on a cumulative numerical scale that included percentage changes in HR, RR and SAP. Postoperative pain was assessed by three independent observers, blinded to treatment, using the UNESP-Botucatu Unidimensional Composite Pain Scale (UNESP-Botucatu UCPS-IV) for the assessment of postoperative pain in cattle. The course of physiological variables was appropriate for patients under anaesthesia. No subject required rescue intraoperative analgesia. In group L, 4 subjects at 40 m and 5 subjects at 50 m required postoperative rescue analgesia. Both butorphanol alone and the combination of butorphanol and lidocaine showed excellent intraoperative and postoperative scores. Furthermore, this combination did not cause any cardiopulmonary or other adverse effects. Based on the results of this study, both butorphanol alone and the co-administration of butorphanol and lidocaine administered locally proved to be safe and effective in providing adequate and long-lasting analgesia in calves, helping to reduce postoperative discomfort and maintaining adequate animal welfare.
本研究的目的是比较布托啡诺和利多卡因单独使用或联合使用时，对接受脐疝手术修复的犊牛的镇痛效果。该研究在60头不同品种的犊牛中进行。对研究中的所有动物肌肉注射0.3mg/kg的赛拉嗪。然后将动物分为三组（每组 = 20头），分别接受4.5mg/kg利多卡因和0.02mg/kg布托啡诺的不同处理。L组通过手术平面浸润和腹腔内注射给予利多卡因，B组通过手术平面浸润和腹腔内注射给予布托啡诺，最后LB组通过手术平面浸润给予利多卡因并腹腔内注射布托啡诺。在手术过程中记录心率、呼吸频率、血红蛋白氧饱和度、无创血压和体温。根据心率、呼吸频率和收缩压的百分比变化，采用累积数字评分法对手术刺激的反应进行评分。由三名独立观察者在不知道治疗情况的前提下，使用UNESP - 博图卡图单维综合疼痛量表（UNESP - 博图卡图UCPS - IV）评估术后疼痛，以评估牛的术后疼痛情况。生理变量的变化过程与麻醉状态下的患者相符。没有受试者需要术中急救镇痛。在L组中，40分钟时有4只动物、50分钟时有5只动物需要术后急救镇痛。单独使用布托啡诺以及布托啡诺与利多卡因联合使用均显示出良好的术中及术后评分。此外，这种联合用药未引起任何心肺或其他不良反应。基于本研究结果，单独使用布托啡诺以及局部联合使用布托啡诺和利多卡因在为犊牛提供充分且持久的镇痛方面被证明是安全有效的，有助于减少术后不适并维持适当的动物福利。
