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在接受脐疝修补术的罗米芬定镇静犊牛的疼痛管理中,静脉推注或缓慢注射曲马多。

Tramadol Administered Intravenously Either as a Bolus or a Slow Injection in Pain Management of Romifidine-Sedated Calves Undergoing Umbilical Hernia Repair.

作者信息

Costa Giovanna L, Leonardi Fabio, Interlandi Claudia, Licata Patrizia, Lizarraga Ignacio, Macrì Francesco, Macrì Daniele, Ferrantelli Vincenzo, Spadola Filippo

机构信息

Department of Veterinary Sciences, University of Messina, Via Palatucci Annunziata, 98168 Messina, Italy.

Department of Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, Italy.

出版信息

Animals (Basel). 2023 Mar 24;13(7):1145. doi: 10.3390/ani13071145.

DOI:10.3390/ani13071145
PMID:37048401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10093555/
Abstract

Umbilical hernias in calves occur with relative frequency. Most abdominal surgeries can be performed in cattle using standing sedation and local blocks. Romifidine is widely used in calves, alone or in combination with opioids. Tramadol administered as an intravenous slow injection provided better analgesia than an IV bolus in cows. The aim of the present study was to compare the response to surgical stimulus, and sedative effects of tramadol administered intravenously either as a bolus or a slow injection in romifidinesedated calves. Twenty Frisian calves undergoing umbilical hernia repair received romifidine (0.08 mg/kg IM; time 0) followed by tramadol (1 mg/kg IV) 5 min later either as a bolus ( = 10, B group) or a slow injection over 10 min ( = 10, SI group). Surgical area was infiltrated with lidocaine (4 mg/kg). Heart rate (HR), respiratory rate (RR), systolic, dyastolic and mean arterial pressure (SAP, DAP, MAP), sedation scores and response to surgical stimulus were recorded for up to 55 min. After the calves recovered a standing position, postoperative pain scores were assessed for up to 50 min. Sedation scores were significantly higher in the SI group than in the B group at 55 min ( < 0.05). HR, RR, SAP and response to surgical stimulus were significantly higher in the B group than in the SI group ( < 0.05). No significant differences were recorded in postoperative pain scores between groups ( > 0.05). Romifidine IM followed by intravenous tramadol, as a bolus or slow injection and local infiltration with lidocaine provided adequate sedation and analgesia in calves undergoing umbilical hernia repair.

摘要

犊牛脐疝相对较为常见。大多数腹部手术可在牛站立镇静和局部阻滞的情况下进行。罗米芬定在犊牛中广泛使用,可单独使用或与阿片类药物联合使用。在奶牛中,静脉缓慢注射曲马多比静脉推注提供更好的镇痛效果。本研究的目的是比较在罗米芬定镇静的犊牛中,静脉推注或缓慢注射曲马多对手术刺激的反应及镇静效果。20头接受脐疝修补术的弗里斯兰犊牛先接受罗米芬定(0.08mg/kg肌肉注射;时间0),5分钟后再接受曲马多(1mg/kg静脉注射),其中10头为推注组(B组),另外10头为10分钟缓慢注射组(SI组)。手术区域用利多卡因(4mg/kg)浸润。记录心率(HR)、呼吸频率(RR)、收缩压、舒张压和平均动脉压(SAP、DAP、MAP)以及镇静评分和对手术刺激的反应,持续55分钟。犊牛恢复站立姿势后,评估术后疼痛评分,持续50分钟。在55分钟时,SI组的镇静评分显著高于B组(P<0.05)。B组的HR、RR、SAP和对手术刺激的反应显著高于SI组(P<0.05)。两组术后疼痛评分无显著差异(P>0.05)。先肌肉注射罗米芬定,然后静脉推注或缓慢注射曲马多,并局部浸润利多卡因,可为接受脐疝修补术的犊牛提供充分的镇静和镇痛。