DeRossi Rafael, Almeida Ricardo G, Medeiros Ulisses, Righetto Fernando R, Frazílio Fabrício O
Department of Veterinary Medicine-Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Federal University of Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil.
Vet J. 2007 May;173(3):658-63. doi: 10.1016/j.tvjl.2006.02.017. Epub 2006 Apr 24.
To determine the efficacy and safety of subarachnoid butorphanol combined with lidocaine, six calves were studied. Each calf underwent two treatments, at least one week apart, via subarachnoid injection: (1) butorphanol (0.03 mg/kg) plus 2% lidocaine (4 mg/kg) and (2) 2% lidocaine (4 mg/kg) alone. Subarachnoid injections were performed at the lumbosacral space. Analgesia, motor block, sedation, heart rate, arterial blood pressure, respiratory rate, arterial oxygen saturation as measured by pulse oximetry, and rectal temperature were compared before and after subarachnoid administration of drugs. Subarachnoid administration of the butorphanol-lidocaine combination induced bilateral prolonged analgesia extending from the coccygeal to the T11-T13 dermatomes in the calves, with minimal sedation and severe ataxia. Cardiovascular effects were significant in both treatments: heart rate was increased, and there was a minimal decrease in arterial pressure. It was concluded that adding a small dose of butorphanol to subarachnoid lidocaine in calves is effective and safe.
为了确定蛛网膜下腔注射布托啡诺联合利多卡因的有效性和安全性，对6头小牛进行了研究。每头小牛通过蛛网膜下腔注射接受两种治疗，间隔至少一周：（1）布托啡诺（0.03 mg/kg）加2%利多卡因（4 mg/kg），（2）单独使用2%利多卡因（4 mg/kg）。在腰骶部间隙进行蛛网膜下腔注射。比较了蛛网膜下腔给药前后的镇痛、运动阻滞、镇静、心率、动脉血压、呼吸频率、经脉搏血氧饱和度测定的动脉血氧饱和度和直肠温度。蛛网膜下腔注射布托啡诺-利多卡因组合在小牛中诱导了从尾骨到T11-T13皮节的双侧长时间镇痛，镇静作用最小且共济失调严重。两种治疗的心血管效应均显著：心率增加，动脉压略有下降。得出的结论是，在小牛蛛网膜下腔利多卡因中添加小剂量布托啡诺是有效且安全的。
