Kamal Abdulkadir, Nairon Emerson B, Bashmakov Anna, Aoun Salah G, Olson DaiWai M
Department of Nursing, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
J Clin Monit Comput. 2025 Feb;39(1):53-58. doi: 10.1007/s10877-024-01234-2. Epub 2024 Oct 18.
Quantitative pupillometry (QP) use has grown exponentially. Each QP scan captures images of the pupil before, during, and after light exposure to provide component measures of the pupillary light reflex (PLR). This study explores if the time to maximum constriction (tMC) is uniform among neuroscience intensive care unit (NSICU) patients. The study enrolled 50 NSICU patients with normal PLR values in a cross-sectional study and adhered to the standard of care for pupil assessments to collect data on tMC within (comparing left eye and right eye) and between patients. The mean tMC of 0.97 (0.17) s was normally distributed across all patients and ranged from 0.46 s to 1.35 s. The mean tMC was similar for the left pupil (0.98 [0.16]s) and right pupil (0.96 [0.18]s; P =.546). The within-subject mean difference (left versus right eye) tMC was 0.13 (0.12)s and ranged from 0.0 to 0.56 s. The between-subject mean tMC was 0.97 (0.17) s and ranged from 0.46 s to 1.35 s. The tMC does not occur at a fixed point in time. Clinical applications that seek to characterize pupil health should account for varied tMC and explore relationships to discrete outcomes to determine the clinical usefulness of tMC.
定量瞳孔测量法（QP）的应用呈指数级增长。每次QP扫描都会捕捉瞳孔在光照前、光照期间和光照后的图像，以提供瞳孔光反射（PLR）的组成测量值。本研究探讨了最大收缩时间（tMC）在神经科学重症监护病房（NSICU）患者中是否一致。该研究在一项横断面研究中纳入了50名PLR值正常的NSICU患者，并遵循瞳孔评估的护理标准，收集患者体内（比较左眼和右眼）以及患者之间tMC的数据。所有患者的平均tMC为0.97（0.17）秒，呈正态分布，范围为0.46秒至1.35秒。左瞳孔的平均tMC（0.98 [0.16]秒）与右瞳孔的平均tMC（0.96 [0.18]秒；P = 0.546）相似。受试者内平均差异（左眼与右眼）tMC为0.13（0.12）秒，范围为0.0至0.56秒。受试者间平均tMC为0.97（0.17）秒，范围为0.46秒至1.35秒。tMC并非发生在固定的时间点。旨在描述瞳孔健康状况的临床应用应考虑到tMC的变化，并探索其与离散结果的关系，以确定tMC的临床实用性。
