Dunn C D, Johnson P C, Lange R D
Aviat Space Environ Med. 1986 Jan;57(1):36-44.
Results are presented which demonstrate a close similarity between the ability of antiorthostatic hypokinetic/hypodynamia and orthostatic hypokinetic/hypodynamia to induce anemia in laboratory rats. The "restraint anemia" (whether mediated directly by reduced activity or indirectly by possible changes in blood circulation or in altered weight-bearing capacity of the skeleton) was largely due to reduced food and/or water consumption and displayed the classical symptoms of inadequate nutrition, i.e. decreased serum erythropoietin (Ep) titers and reduced Ep sensitivity of hematopoietic tissue. Only changes in red blood cell (RBC) clearance were unique to the head-down (antiorthostatic) posture. During suspension, RBC clearance was reduced and then accelerated when suspension was terminated or the cells transfused into a normal environment. Changes in RBC clearance were due to both cell-associated and cell-independent factors and may be related to the alterations in RBC survival seen in rats during or immediately after space flight. In both suspension and weightlessness, these changes were limited to alterations in the force and/or direction of the gravity vector.
研究结果表明，在诱导实验大鼠贫血方面，抗直立性运动减少/动力不足与直立性运动减少/动力不足的能力极为相似。“束缚性贫血”（无论直接由活动减少介导，还是间接由血液循环变化或骨骼负重能力改变介导）很大程度上是由于食物和/或水摄入减少所致，并表现出营养不良的典型症状，即血清促红细胞生成素（Ep）滴度降低以及造血组织对Ep的敏感性降低。只有红细胞（RBC）清除率的变化是头低位（抗直立性）姿势所特有的。在悬吊期间，RBC清除率降低，而当悬吊终止或将细胞输注到正常环境中时则加速。RBC清除率的变化是由细胞相关和细胞非相关因素共同导致的，并且可能与大鼠在太空飞行期间或之后立即出现的RBC存活变化有关。在悬吊和失重状态下，这些变化都仅限于重力矢量的力和/或方向的改变。
