Zhang Zixuan, Bai Jing, Zhang Siqi, Wang Renzhen, Zhu Shaobing, Li Tianyue, Zhang Miao
Graduate Schools, Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, People's Republic of China.
Acupuncture and Moxibustion 10 Departments, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, People's Republic of China.
Int J Gen Med. 2024 Oct 16;17:4723-4732. doi: 10.2147/IJGM.S478479. eCollection 2024.
Alzheimer's disease (AD) is a progressive neurodegenerative disease caused by multiple causes. The main pathological features of AD are β-amyloid (Aβ) deposition, hyperphosphorylation of Tau protein, and progressive neuronal loss. Pyroptosis is one of the main forms of neuronal death, which is mainly caused by the activation of Gasdermin protein by upstream signals and the release of its N-terminal domain on the cell membrane. Studies have shown that there is a close relationship between Alzheimer's disease (AD) and pyroptosis. Therefore, this paper summarizes the relationship between pyroptosis and its molecular mechanism and AD, as well as the related research of traditional Chinese medicine in the treatment of AD by regulating pyroptosis, in order to provide a new direction for the study of AD pathogenesis based on pyroptosis pathway.
阿尔茨海默病（AD）是一种由多种病因引起的进行性神经退行性疾病。AD的主要病理特征是β-淀粉样蛋白（Aβ）沉积、Tau蛋白过度磷酸化以及神经元进行性丧失。细胞焦亡是神经元死亡的主要形式之一，主要由上游信号激活Gasdermin蛋白并使其N端结构域在细胞膜上释放所引起。研究表明，阿尔茨海默病（AD）与细胞焦亡之间存在密切关系。因此，本文综述了细胞焦亡及其分子机制与AD的关系，以及中药通过调控细胞焦亡治疗AD的相关研究，以期为基于细胞焦亡途径的AD发病机制研究提供新方向。
