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来氟米特治疗患者出现的空洞性肺类风湿结节:一例报告

Cavitary pulmonary rheumatoid nodules in a patient on leflunomide: A case report.

作者信息

Coulibaly Abidou Kawélé, Henchiri Imen, Meunier Marine, Saint-Marcoux Bernadette

机构信息

Rheumatology Department, Cocody University Hospital, Abidjan, Côte d'Ivoire.

Robert Ballanger Intercommunal Hospital, Aulnay Sous Bois, France.

出版信息

Radiol Case Rep. 2024 Oct 3;19(12):6662-6666. doi: 10.1016/j.radcr.2024.09.094. eCollection 2024 Dec.

DOI:10.1016/j.radcr.2024.09.094
PMID:39430227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11489126/
Abstract

Rheumatoid arthritis is a chronic inflammatory rheumatic disease that can cause extra-articular manifestations, in particular pleuropulmonary involvement, which is the second leading cause of death in this connective tissue disease. We report a rare pulmonary manifestation of RA. This was a 58-year-old patient being followed for RA on leflunomide with 3 excavated pulmonary nodules measuring 13 mm, 10 mm and 6 mm, for which the diagnostic hypotheses of infection, pulmonary metastases and rheumatoid nodules had been put forward. The diagnosis of excavated pulmonary nodules in rheumatoid arthritis was made after aspiration of one of the nodules, which ruled out infectious and cancerous causes. These nodules regressed 6 months after leflunomide was stopped.

摘要

类风湿关节炎是一种慢性炎症性风湿性疾病,可导致关节外表现,尤其是胸膜肺部受累,这是这种结缔组织病的第二大死亡原因。我们报告一例类风湿关节炎罕见的肺部表现。这是一名58岁的患者,因类风湿关节炎接受来氟米特治疗,有3个空洞性肺结节,大小分别为13毫米、10毫米和6毫米,曾提出感染、肺转移和类风湿结节的诊断假设。在对其中一个结节进行抽吸后,排除了感染和癌症原因,从而诊断为类风湿关节炎的空洞性肺结节。停用 来氟米特6个月后,这些结节消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/bbf9c1108500/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/b94de0749775/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/6c61b289a4e2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/b0f77302c806/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/bbf9c1108500/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/b94de0749775/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/6c61b289a4e2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/b0f77302c806/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d9/11489126/bbf9c1108500/gr4.jpg

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Clin Rheumatol. 2024 Feb;43(2):775-784. doi: 10.1007/s10067-023-06773-8. Epub 2023 Sep 23.
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Pulmonary Manifestations of Rheumatoid Arthritis.
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A case of rheumatoid arthritis with multiple lung rheumatoid nodules successfully treated with tofacitinib.一例类风湿关节炎伴多发肺部类风湿结节患者经托法替布治疗后获得良好疗效。
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