两例II期神经母细胞瘤中的（19；？）易位

Translocation (19;?) in two stage II neuroblastomas.

作者信息

Franke F, Rudolph B, Lampert F

出版信息

Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):129-35. doi: 10.1016/0165-4608(86)90116-0.

Abstract

Chromosomes of two abdominal neuroblastomas (stage II) from a 10-month-old male infant and a 6-year-old girl were analyzed. A modal chromosome number of 70 and 46, respectively, was found. Neither double minute chromosomes (DM) or homogeneously staining regions (HSR), nor visible structural abnormalities of chromosome #1 could be detected. However, a common aberration was found to be a translocation on the short arm of chromosome #19. After tumor resection, both children are alive without any evidence of tumor disease.

摘要

对一名10个月大男婴和一名6岁女孩的两个腹部神经母细胞瘤（II期）的染色体进行了分析。分别发现其众数染色体数为70和46。未检测到双微体染色体（DM）或均匀染色区（HSR），也未发现1号染色体可见的结构异常。然而，发现一个常见的畸变是19号染色体短臂上的易位。肿瘤切除后，两个孩子均存活，且无任何肿瘤疾病迹象。